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Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.
Salazar M, Lorente M, García-Taboada E, Pérez Gómez E, Dávila D, Zúñiga-García P, María Flores J, Rodríguez A, Hegedus Z, Mosén-Ansorena D, Aransay AM, Hernández-Tiedra S, López-Valero I, Quintanilla M, Sánchez C, Iovanna JL, Dusetti N, Guzmán M, Francis SE, Carracedo A, Kiss-Toth E, Velasco G. Salazar M, et al. Among authors: francis se. Cell Death Differ. 2015 Jan;22(1):131-44. doi: 10.1038/cdd.2014.133. Epub 2014 Aug 29. Cell Death Differ. 2015. PMID: 25168244 Free PMC article.
TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.
Salazar M, Lorente M, García-Taboada E, Gómez EP, Dávila D, Zúñiga-García P, Flores JM, Rodríguez A, Hegedus Z, Mosén-Ansorena D, Aransay AM, Hernández-Tiedra S, López-Valero I, Quintanilla M, Sánchez C, Iovanna JL, Dusetti N, Guzmán M, Francis SE, Carracedo A, Kiss-Toth E, Velasco G. Salazar M, et al. Among authors: francis se. Mol Cell Oncol. 2015 Apr 18;2(3):e980134. doi: 10.4161/23723556.2014.980134. eCollection 2015 Jul-Sep. Mol Cell Oncol. 2015. PMID: 27308456 Free PMC article.
Tribbles in inflammation.
Johnston J, Basatvat S, Ilyas Z, Francis S, Kiss-Toth E. Johnston J, et al. Biochem Soc Trans. 2015 Oct;43(5):1069-74. doi: 10.1042/BST20150095. Biochem Soc Trans. 2015. PMID: 26517925 Review.
Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M; Cardiogenics Consortium; Wilson HL, Goodall AH, Rader DJ, Shoulders CC, Francis SE, Kiss-Toth E. Johnston JM, et al. Among authors: francis se. Sci Adv. 2019 Oct 30;5(10):eaax9183. doi: 10.1126/sciadv.aax9183. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31692955 Free PMC article.
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK, Francis SE, Crossman DC, Kiss-Toth E. Eder K, et al. Among authors: francis se. Int Immunol. 2008 Dec;20(12):1543-50. doi: 10.1093/intimm/dxn116. Epub 2008 Oct 24. Int Immunol. 2008. PMID: 18952906 Free PMC article.
Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling.
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE, Kiss-Toth E, Wilson HL. Martinez-Campesino L, et al. Among authors: francis se. Front Cardiovasc Med. 2022 Aug 26;9:948461. doi: 10.3389/fcvm.2022.948461. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36158793 Free PMC article.
150 results