Decker M - Search Results

1

Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.

Chen X, Klöckner J, Holze J, Zimmermann C, Seemann WK, Schrage R, Bock A, Mohr K, Tränkle C, Holzgrabe U, Decker M. Chen X, et al. Among authors: decker m. J Med Chem. 2015 Jan 22;58(2):560-76. doi: 10.1021/jm500860w. Epub 2014 Dec 19. J Med Chem. 2015. PMID: 25478907

2

Enantioseparation of linear and cyclic chiral bis(phenethyl)amines by means of cyclodextrin-modified capillary electrophoresis.

Wedig M, Thunhorst M, Laug S, Decker M, Lehmann J, Holzgrabe U. Wedig M, et al. Among authors: decker m. Fresenius J Anal Chem. 2001 Sep;371(2):212-7. doi: 10.1007/s002160100961. Fresenius J Anal Chem. 2001. PMID: 11678194

3

Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.

Hoefgen B, Decker M, Mohr P, Schramm AM, Rostom SA, El-Subbagh H, Schweikert PM, Rudolf DR, Kassack MU, Lehmann J. Hoefgen B, et al. Among authors: decker m. J Med Chem. 2006 Jan 26;49(2):760-9. doi: 10.1021/jm050846j. J Med Chem. 2006. PMID: 16420061

4

Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist.

Mohr P, Decker M, Enzensperger C, Lehmann J. Mohr P, et al. Among authors: decker m. J Med Chem. 2006 Mar 23;49(6):2110-6. doi: 10.1021/jm051237e. J Med Chem. 2006. PMID: 16539400

5

In vivo investigations on the cholinesterase-inhibiting effects of tricyclic quinazolinimines: scopolamine-induced cognitive impairments in rats are attenuated at low dosage and reinforced at higher dosage.

Appenroth D, Decker M, Tränkle C, Mohr K, Lehmann J, Fleck C. Appenroth D, et al. Among authors: decker m. Pflugers Arch. 2008 Feb;455(5):895-901. doi: 10.1007/s00424-007-0325-0. Epub 2007 Aug 24. Pflugers Arch. 2008. PMID: 17717685

6

NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.

Fang L, Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J. Fang L, et al. Among authors: decker m. J Med Chem. 2008 Dec 25;51(24):7666-9. doi: 10.1021/jm801131a. J Med Chem. 2008. PMID: 19053746

7

Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands.

Decker M, Fulton BS, Zhang B, Knapp BI, Bidlack JM, Neumeyer JL. Decker M, et al. J Med Chem. 2009 Dec 10;52(23):7389-96. doi: 10.1021/jm900379p. J Med Chem. 2009. PMID: 19634902 Free PMC article.

8

Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.

Fang L, Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Tränkle C, Decker M. Fang L, et al. Among authors: decker m. J Med Chem. 2010 Mar 11;53(5):2094-103. doi: 10.1021/jm901616h. J Med Chem. 2010. PMID: 20158205

9

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.

Chen X, Tikhonova IG, Decker M. Chen X, et al. Among authors: decker m. Bioorg Med Chem. 2011 Feb 1;19(3):1222-35. doi: 10.1016/j.bmc.2010.12.034. Epub 2010 Dec 21. Bioorg Med Chem. 2011. PMID: 21232964

10

Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.

Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MA, Cordell GA. Macabeo AP, et al. Among authors: decker m. Eur J Med Chem. 2011 Jul;46(7):3118-23. doi: 10.1016/j.ejmech.2011.04.025. Epub 2011 Apr 19. Eur J Med Chem. 2011. PMID: 21546135

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