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Development of novel ACK1/TNK2 inhibitors using a fragment-based approach.
Lawrence HR, Mahajan K, Luo Y, Zhang D, Tindall N, Huseyin M, Gevariya H, Kazi S, Ozcan S, Mahajan NP, Lawrence NJ. Lawrence HR, et al. Among authors: mahajan k, mahajan np. J Med Chem. 2015 Mar 26;58(6):2746-63. doi: 10.1021/jm501929n. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25699576 Free PMC article.
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP. Mahajan K, et al. Among authors: mahajan np. PLoS One. 2010 Mar 19;5(3):e9646. doi: 10.1371/journal.pone.0009646. PLoS One. 2010. PMID: 20333297 Free PMC article.
WEE1 tyrosine kinase, a novel epigenetic modifier.
Mahajan K, Mahajan NP. Mahajan K, et al. Among authors: mahajan np. Trends Genet. 2013 Jul;29(7):394-402. doi: 10.1016/j.tig.2013.02.003. Epub 2013 Mar 26. Trends Genet. 2013. PMID: 23537585 Free PMC article. Review.
341 results