Smithies O - Search Results

1

Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.

Koller BH, Hagemann LJ, Doetschman T, Hagaman JR, Huang S, Williams PJ, First NL, Maeda N, Smithies O. Koller BH, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8927-31. doi: 10.1073/pnas.86.22.8927. Proc Natl Acad Sci U S A. 1989. PMID: 2573070 Free PMC article.

2

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

Doetschman T, Maeda N, Smithies O. Doetschman T, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8583-7. doi: 10.1073/pnas.85.22.8583. Proc Natl Acad Sci U S A. 1988. PMID: 3186749 Free PMC article.

3

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.

Smithies O, Maeda N. Smithies O, et al. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5266-72. doi: 10.1073/pnas.92.12.5266. Proc Natl Acad Sci U S A. 1995. PMID: 7777495 Free PMC article. Review.

4

Single-copy transgenic mice with chosen-site integration.

Bronson SK, Plaehn EG, Kluckman KD, Hagaman JR, Maeda N, Smithies O. Bronson SK, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9067-72. doi: 10.1073/pnas.93.17.9067. Proc Natl Acad Sci U S A. 1996. PMID: 8799155 Free PMC article.

5

Altering genes in animals by gene targeting.

Koller BH, Smithies O. Koller BH, et al. Among authors: smithies o. Annu Rev Immunol. 1992;10:705-30. doi: 10.1146/annurev.iy.10.040192.003421. Annu Rev Immunol. 1992. PMID: 1591000 Review.

6

Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells.

Koller BH, Kim HS, Latour AM, Brigman K, Boucher RC Jr, Scambler P, Wainwright B, Smithies O. Koller BH, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10730-4. doi: 10.1073/pnas.88.23.10730. Proc Natl Acad Sci U S A. 1991. PMID: 1720548 Free PMC article.

7

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.

Reid LH, Gregg RG, Smithies O, Koller BH. Reid LH, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 1990 Jun;87(11):4299-303. doi: 10.1073/pnas.87.11.4299. Proc Natl Acad Sci U S A. 1990. PMID: 2349238 Free PMC article.

8

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

Koller BH, Smithies O. Koller BH, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8932-5. doi: 10.1073/pnas.86.22.8932. Proc Natl Acad Sci U S A. 1989. PMID: 2682666 Free PMC article.

9

Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males.

Caron K, Hagaman J, Nishikimi T, Kim HS, Smithies O. Caron K, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3420-5. doi: 10.1073/pnas.0611365104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360661 Free PMC article.

10

Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.

Pandya K, Cowhig J, Brackhan J, Kim HS, Hagaman J, Rojas M, Carter CW Jr, Mao L, Rockman HA, Maeda N, Smithies O. Pandya K, et al. Among authors: smithies o. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13063-8. doi: 10.1073/pnas.0805120105. Epub 2008 Aug 28. Proc Natl Acad Sci U S A. 2008. PMID: 18755891 Free PMC article.

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