Jacobson MP - Search Results

1

Synthesis and enzymatic studies of bisubstrate analogues for farnesyl diphosphate synthase.

Ramamoorthy G, Pugh ML, Tian BX, Phan RM, Perez LB, Jacobson MP, Poulter CD. Ramamoorthy G, et al. Among authors: jacobson mp. J Org Chem. 2015 Apr 17;80(8):3902-13. doi: 10.1021/acs.joc.5b00202. Epub 2015 Mar 26. J Org Chem. 2015. PMID: 25734506

2

Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.

Wallrapp FH, Pan JJ, Ramamoorthy G, Almonacid DE, Hillerich BS, Seidel R, Patskovsky Y, Babbitt PC, Almo SC, Jacobson MP, Poulter CD. Wallrapp FH, et al. Among authors: jacobson mp. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):E1196-202. doi: 10.1073/pnas.1300632110. Epub 2013 Mar 14. Proc Natl Acad Sci U S A. 2013. PMID: 23493556 Free PMC article.

3

Predicting enzyme-substrate specificity with QM/MM methods: a case study of the stereospecificity of (D)-glucarate dehydratase.

Tian B, Wallrapp F, Kalyanaraman C, Zhao S, Eriksson LA, Jacobson MP. Tian B, et al. Among authors: jacobson mp. Biochemistry. 2013 Aug 20;52(33):5511-3. doi: 10.1021/bi400546j. Epub 2013 Aug 9. Biochemistry. 2013. PMID: 23901785 Free PMC article.

4

Leveraging structure for enzyme function prediction: methods, opportunities, and challenges.

Jacobson MP, Kalyanaraman C, Zhao S, Tian B. Jacobson MP, et al. Trends Biochem Sci. 2014 Aug;39(8):363-71. doi: 10.1016/j.tibs.2014.05.006. Epub 2014 Jul 2. Trends Biochem Sci. 2014. PMID: 24998033 Free PMC article. Review.

5

Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.

Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. Krishnan S, et al. Among authors: jacobson mp. J Am Chem Soc. 2014 Sep 10;136(36):12624-30. doi: 10.1021/ja505194w. Epub 2014 Sep 2. J Am Chem Soc. 2014. PMID: 25153195 Free PMC article.

6

Predicting the functions and specificity of triterpenoid synthases: a mechanism-based multi-intermediate docking approach.

Tian BX, Wallrapp FH, Holiday GL, Chow JY, Babbitt PC, Poulter CD, Jacobson MP. Tian BX, et al. Among authors: jacobson mp. PLoS Comput Biol. 2014 Oct 9;10(10):e1003874. doi: 10.1371/journal.pcbi.1003874. eCollection 2014 Oct. PLoS Comput Biol. 2014. PMID: 25299649 Free PMC article.

7

Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus.

Chow JY, Tian BX, Ramamoorthy G, Hillerich BS, Seidel RD, Almo SC, Jacobson MP, Poulter CD. Chow JY, et al. Among authors: jacobson mp. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5661-6. doi: 10.1073/pnas.1505127112. Epub 2015 Apr 21. Proc Natl Acad Sci U S A. 2015. PMID: 25901324 Free PMC article.

8

Defining the Product Chemical Space of Monoterpenoid Synthases.

Tian B, Poulter CD, Jacobson MP. Tian B, et al. Among authors: jacobson mp. PLoS Comput Biol. 2016 Aug 12;12(8):e1005053. doi: 10.1371/journal.pcbi.1005053. eCollection 2016 Aug. PLoS Comput Biol. 2016. PMID: 27517297 Free PMC article.

9

Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen.

de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. de Jesus Cortez F, et al. Among authors: jacobson mp. ACS Chem Biol. 2017 Dec 15;12(12):2934-2939. doi: 10.1021/acschembio.7b00702. Epub 2017 Nov 2. ACS Chem Biol. 2017. PMID: 28981251

10

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.

Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. Bruning JM, et al. Among authors: jacobson mp. Cell Chem Biol. 2019 May 16;26(5):674-685.e6. doi: 10.1016/j.chembiol.2019.02.002. Epub 2019 Mar 7. Cell Chem Biol. 2019. PMID: 30853418 Free PMC article.

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