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RPF151, a novel capsaicin-like analogue: in vitro studies and in vivo preclinical antitumor evaluation in a breast cancer model.
Ferreira AK, Tavares MT, Pasqualoto KF, de Azevedo RA, Teixeira SF, Ferreira-Junior WA, Bertin AM, de-Sá-Junior PL, Barbuto JA, Figueiredo CR, Cury Y, Damião MC, Parise-Filho R. Ferreira AK, et al. Among authors: pasqualoto kf. Tumour Biol. 2015 Sep;36(9):7251-67. doi: 10.1007/s13277-015-3441-z. Epub 2015 Apr 20. Tumour Biol. 2015. PMID: 25894379
RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells.
de-Sá-Júnior PL, Pasqualoto KF, Ferreira AK, Tavares MT, Damião MC, de Azevedo RA, Câmara DA, Pereira A, de Souza DM, Parise Filho R. de-Sá-Júnior PL, et al. Among authors: pasqualoto kf. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):385-98. doi: 10.1016/j.taap.2012.11.029. Epub 2012 Dec 10. Toxicol Appl Pharmacol. 2013. PMID: 23238560
Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network.
Ferreira AK, de-Sá-Júnior PL, Pasqualoto KF, de Azevedo RA, Câmara DA, Costa AS, Figueiredo CR, Matsuo AL, Massaoka MH, Auada AV, Lebrun I, Damião MC, Tavares MT, Magri FM, Kerkis I, Parise Filho R. Ferreira AK, et al. Among authors: pasqualoto kf. Biochimie. 2014 Apr;99:195-207. doi: 10.1016/j.biochi.2013.12.008. Epub 2013 Dec 16. Biochimie. 2014. PMID: 24355203
BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity.
Ferreira AK, Pasqualoto KF, Kruyt FA, Palace-Berl F, Azevedo RA, Turra KM, Rodrigues CP, Ferreira AC, Salomón MA, de Sá Junior PL, Farias CF, Figueiredo CR, Tavares LC, Barbuto JA, Jorge SD. Ferreira AK, et al. Among authors: pasqualoto kf. Toxicol Appl Pharmacol. 2016 Mar 15;295:56-67. doi: 10.1016/j.taap.2016.02.008. Epub 2016 Feb 10. Toxicol Appl Pharmacol. 2016. PMID: 26876618
Designing and exploring active N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients.
Palace-Berl F, Pasqualoto KF, Jorge SD, Zingales B, Zorzi RR, Silva MN, Ferreira AK, de Azevedo RA, Teixeira SF, Tavares LC. Palace-Berl F, et al. Among authors: pasqualoto kf. Eur J Med Chem. 2015;96:330-9. doi: 10.1016/j.ejmech.2015.03.066. Epub 2015 Apr 1. Eur J Med Chem. 2015. PMID: 25899337
Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro.
Júnior PL, Câmara DA, Costa AS, Ruiz JL, Levy D, Azevedo RA, Pasqualoto KF, de Oliveira CF, de Melo TC, Pessoa ND, Fonseca PM, Pereira A, Araldi RP, Ferreira AK. Júnior PL, et al. Among authors: pasqualoto kf. Phytomedicine. 2016 Jun 15;23(7):725-35. doi: 10.1016/j.phymed.2016.03.014. Epub 2016 Apr 16. Phytomedicine. 2016. PMID: 27235711 Free article.
5-Nitro-2-furfuriliden derivatives as potential anti-Trypanosoma cruzi agents: design, synthesis, bioactivity evaluation, cytotoxicity and exploratory data analysis.
Palace-Berl F, Jorge SD, Pasqualoto KF, Ferreira AK, Maria DA, Zorzi RR, de Sá Bortolozzo L, Lindoso JÂ, Tavares LC. Palace-Berl F, et al. Among authors: pasqualoto kf. Bioorg Med Chem. 2013 Sep 1;21(17):5395-406. doi: 10.1016/j.bmc.2013.06.017. Epub 2013 Jun 15. Bioorg Med Chem. 2013. PMID: 23816040 Free article.
43 results