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RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells.
de-Sá-Júnior PL, Pasqualoto KF, Ferreira AK, Tavares MT, Damião MC, de Azevedo RA, Câmara DA, Pereira A, de Souza DM, Parise Filho R. de-Sá-Júnior PL, et al. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):385-98. doi: 10.1016/j.taap.2012.11.029. Epub 2012 Dec 10. Toxicol Appl Pharmacol. 2013. PMID: 23238560
Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo.
de Azevedo RA, Figueiredo CR, Ferreira AK, Matsuo AL, Massaoka MH, Girola N, Auada AV, Farias CF, Pasqualoto KF, Rodrigues CP, Barbuto JA, Levy D, Bydlowski SP, de Sá-Junior PL, Travassos LR, Lebrun I. de Azevedo RA, et al. Peptides. 2015 Jun;68:113-9. doi: 10.1016/j.peptides.2014.09.024. Epub 2014 Oct 14. Peptides. 2015. PMID: 25305549
Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network.
Ferreira AK, de-Sá-Júnior PL, Pasqualoto KF, de Azevedo RA, Câmara DA, Costa AS, Figueiredo CR, Matsuo AL, Massaoka MH, Auada AV, Lebrun I, Damião MC, Tavares MT, Magri FM, Kerkis I, Parise Filho R. Ferreira AK, et al. Biochimie. 2014 Apr;99:195-207. doi: 10.1016/j.biochi.2013.12.008. Epub 2013 Dec 16. Biochimie. 2014. PMID: 24355203
BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity.
Ferreira AK, Pasqualoto KF, Kruyt FA, Palace-Berl F, Azevedo RA, Turra KM, Rodrigues CP, Ferreira AC, Salomón MA, de Sá Junior PL, Farias CF, Figueiredo CR, Tavares LC, Barbuto JA, Jorge SD. Ferreira AK, et al. Among authors: de sa junior pl. Toxicol Appl Pharmacol. 2016 Mar 15;295:56-67. doi: 10.1016/j.taap.2016.02.008. Epub 2016 Feb 10. Toxicol Appl Pharmacol. 2016. PMID: 26876618
The Roles of ROS in Cancer Heterogeneity and Therapy.
de Sá Junior PL, Câmara DAD, Porcacchia AS, Fonseca PMM, Jorge SD, Araldi RP, Ferreira AK. de Sá Junior PL, et al. Oxid Med Cell Longev. 2017;2017:2467940. doi: 10.1155/2017/2467940. Epub 2017 Oct 16. Oxid Med Cell Longev. 2017. PMID: 29123614 Free PMC article. Review.
Genetics and metabolic deregulation following cancer initiation: A world to explore.
Araldi RP, Módolo DG, de Sá Júnior PL, Consonni SR, de Carvalho RF, Roperto FP, Beçak W, de Cassia Stocco R. Araldi RP, et al. Among authors: de sa junior pl. Biomed Pharmacother. 2016 Aug;82:449-58. doi: 10.1016/j.biopha.2016.05.031. Epub 2016 Jun 1. Biomed Pharmacother. 2016. PMID: 27470384 Review.
Using the comet and micronucleus assays for genotoxicity studies: A review.
Araldi RP, de Melo TC, Mendes TB, de Sá Júnior PL, Nozima BH, Ito ET, de Carvalho RF, de Souza EB, de Cassia Stocco R. Araldi RP, et al. Biomed Pharmacother. 2015 May;72:74-82. doi: 10.1016/j.biopha.2015.04.004. Epub 2015 Apr 14. Biomed Pharmacother. 2015. PMID: 26054678 Review.
Toxin bioportides: exploring toxin biological activity and multifunctionality.
Kerkis I, de Brandão Prieto da Silva AR, Pompeia C, Tytgat J, de Sá Junior PL. Kerkis I, et al. Among authors: de sa junior pl. Cell Mol Life Sci. 2017 Feb;74(4):647-661. doi: 10.1007/s00018-016-2343-6. Epub 2016 Aug 23. Cell Mol Life Sci. 2017. PMID: 27554773 Free PMC article. Review.
18 results