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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.
Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ. Khor B, et al. Elife. 2015 May 22;4:e05920. doi: 10.7554/eLife.05920. Elife. 2015. PMID: 25998054 Free PMC article.
Signal transduction and Th17 cell differentiation.
O'Shea JJ, Steward-Tharp SM, Laurence A, Watford WT, Wei L, Adamson AS, Fan S. O'Shea JJ, et al. Microbes Infect. 2009 Apr;11(5):599-611. doi: 10.1016/j.micinf.2009.04.007. Epub 2009 Apr 18. Microbes Infect. 2009. PMID: 19379825 Free PMC article. Review.
Immune modulation: Turncoat regulatory T cells.
Gadina M, O'Shea JJ. Gadina M, et al. Nat Med. 2009 Dec;15(12):1365. doi: 10.1038/nm1209-1365. Nat Med. 2009. PMID: 19966774 Free PMC article. No abstract available.
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP. Roychoudhuri R, et al. Nature. 2013 Jun 27;498(7455):506-10. doi: 10.1038/nature12199. Epub 2013 Jun 2. Nature. 2013. PMID: 23728300 Free PMC article.
Super-enhancers delineate disease-associated regulatory nodes in T cells.
Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, Erdos MR, Davis SR, Roychoudhuri R, Restifo NP, Gadina M, Tang Z, Ruan Y, Collins FS, Sartorelli V, O'Shea JJ. Vahedi G, et al. Nature. 2015 Apr 23;520(7548):558-62. doi: 10.1038/nature14154. Epub 2015 Feb 16. Nature. 2015. PMID: 25686607 Free PMC article.
367 results