Omura S - Search Results

1

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.

Sugawara A, Maita N, Gouda H, Yamamoto T, Hirose T, Kimura S, Saito Y, Nakano H, Kasai T, Nakano H, Shiomi K, Hirono S, Watanabe T, Taniguchi H, Omura S, Sunazuka T. Sugawara A, et al. Among authors: omura s. J Med Chem. 2015 Jun 25;58(12):4984-97. doi: 10.1021/acs.jmedchem.5b00175. Epub 2015 Jun 12. J Med Chem. 2015. PMID: 26030312

2

Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity.

Sugawara A, Sunazuka T, Hirose T, Nagai K, Yamaguchi Y, Hanaki H, Sharpless KB, Omura S. Sugawara A, et al. Among authors: omura s. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6340-4. doi: 10.1016/j.bmcl.2007.08.068. Epub 2007 Sep 1. Bioorg Med Chem Lett. 2007. PMID: 17869508

3

Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.

Gouda H, Yanai Y, Sugawara A, Sunazuka T, Omura S, Hirono S. Gouda H, et al. Among authors: omura s. Bioorg Med Chem. 2008 Apr 1;16(7):3565-79. doi: 10.1016/j.bmc.2008.02.017. Epub 2008 Feb 8. Bioorg Med Chem. 2008. PMID: 18313305

4

Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.

Sunazuka T, Sugawara A, Iguchi K, Hirose T, Nagai K, Noguchi Y, Saito Y, Yamamoto T, Ui H, Gouda H, Shiomi K, Watanabe T, Omura S. Sunazuka T, et al. Among authors: omura s. Bioorg Med Chem. 2009 Apr 1;17(7):2751-8. doi: 10.1016/j.bmc.2009.02.047. Epub 2009 Feb 27. Bioorg Med Chem. 2009. PMID: 19297173

5

Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry.

Hirose T, Sunazuka T, Sugawara A, Endo A, Iguchi K, Yamamoto T, Ui H, Shiomi K, Watanabe T, Sharpless KB, Omura S. Hirose T, et al. Among authors: omura s. J Antibiot (Tokyo). 2009 May;62(5):277-82. doi: 10.1038/ja.2009.28. Epub 2009 Mar 27. J Antibiot (Tokyo). 2009. PMID: 19329983

6

Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens.

Gouda H, Sunazuka T, Iguchi K, Sugawara A, Hirose T, Noguchi Y, Saito Y, Yanai Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S. Gouda H, et al. Among authors: omura s. Bioorg Med Chem Lett. 2009 May 15;19(10):2630-3. doi: 10.1016/j.bmcl.2009.04.013. Epub 2009 Apr 9. Bioorg Med Chem Lett. 2009. PMID: 19395258

7

Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.

Gouda H, Terashima S, Iguchi K, Sugawara A, Saito Y, Yamamoto T, Hirose T, Shiomi K, Sunazuka T, Omura S, Hirono S. Gouda H, et al. Among authors: omura s. Bioorg Med Chem. 2009 Sep 1;17(17):6270-8. doi: 10.1016/j.bmc.2009.07.045. Epub 2009 Jul 25. Bioorg Med Chem. 2009. PMID: 19666229

8

Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms.

Hirose T, Sunazuka T, Omura S. Hirose T, et al. Among authors: omura s. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):85-102. doi: 10.2183/pjab.86.85. Proc Jpn Acad Ser B Phys Biol Sci. 2010. PMID: 20154467 Free PMC article. Review.

9

NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.

Gouda H, Sunazuka T, Hirose T, Iguchi K, Yamaotsu N, Sugawara A, Noguchi Y, Saito Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S. Gouda H, et al. Among authors: omura s. Bioorg Med Chem. 2010 Aug 15;18(16):5835-44. doi: 10.1016/j.bmc.2010.06.093. Epub 2010 Jul 1. Bioorg Med Chem. 2010. PMID: 20667742

10

Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents.

Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T. Sugawara A, et al. Among authors: omura s. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3373-6. doi: 10.1016/j.bmcl.2011.04.004. Epub 2011 Apr 7. Bioorg Med Chem Lett. 2011. PMID: 21524580

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