Polt R - Search Results

1

Structural Requirements for CNS Active Opioid Glycopeptides.

Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Lefever M, et al. Among authors: polt r. J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23. J Med Chem. 2015. PMID: 26125201

2

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Polt R, et al. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7114-8. doi: 10.1073/pnas.91.15.7114. Proc Natl Acad Sci U S A. 1994. PMID: 8041755 Free PMC article.

3

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Bilsky EJ, et al. Among authors: polt r. J Med Chem. 2000 Jun 29;43(13):2586-90. doi: 10.1021/jm000077y. J Med Chem. 2000. PMID: 10891118

4

O-Linked glycopeptides retain helicity in water.

Palian MM, Jacobsen NE, Polt R. Palian MM, et al. Among authors: polt r. J Pept Res. 2001 Aug;58(2):180-9. doi: 10.1034/j.1399-3011.2001.00906.x. J Pept Res. 2001. PMID: 11532077

5

Glycopeptide-membrane interactions: glycosyl enkephalin analogues adopt turn conformations by NMR and CD in amphipathic media.

Palian MM, Boguslavsky VI, O'Brien DF, Polt R. Palian MM, et al. Among authors: polt r. J Am Chem Soc. 2003 May 14;125(19):5823-31. doi: 10.1021/ja0268635. J Am Chem Soc. 2003. PMID: 12733923

6

Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.

Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Elmagbari NO, et al. Among authors: polt r. J Pharmacol Exp Ther. 2004 Oct;311(1):290-7. doi: 10.1124/jpet.104.069393. Epub 2004 May 27. J Pharmacol Exp Ther. 2004. PMID: 15166257

7

Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.

Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Dhanasekaran M, et al. Among authors: polt r. J Am Chem Soc. 2005 Apr 20;127(15):5435-48. doi: 10.1021/ja0432158. J Am Chem Soc. 2005. PMID: 15826181

8

Glycosylated neuropeptides: a new vista for neuropsychopharmacology?

Polt R, Dhanasekaran M, Keyari CM. Polt R, et al. Med Res Rev. 2005 Sep;25(5):557-85. doi: 10.1002/med.20039. Med Res Rev. 2005. PMID: 16075406 Review.

9

Glycosylation improves the central effects of DAMGO.

Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Lowery JJ, et al. Among authors: polt r. Chem Biol Drug Des. 2007 Jan;69(1):41-7. doi: 10.1111/j.1747-0285.2007.00462.x. Chem Biol Drug Des. 2007. PMID: 17313456

10

Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys.

Do Carmo GP, Polt R, Bilsky EJ, Rice KC, Negus SS. Do Carmo GP, et al. Among authors: polt r. J Pharmacol Exp Ther. 2008 Sep;326(3):939-48. doi: 10.1124/jpet.108.138180. Epub 2008 May 29. J Pharmacol Exp Ther. 2008. PMID: 18511649 Free PMC article.

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