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B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.
Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. Recher M, et al. Blood. 2012 Mar 22;119(12):2819-28. doi: 10.1182/blood-2011-09-379412. Epub 2012 Feb 1. Blood. 2012. PMID: 22302739 Free PMC article.
N-wasp is essential for the negative regulation of B cell receptor signaling.
Liu C, Bai X, Wu J, Sharma S, Upadhyaya A, Dahlberg CI, Westerberg LS, Snapper SB, Zhao X, Song W. Liu C, et al. Among authors: westerberg ls. PLoS Biol. 2013 Nov;11(11):e1001704. doi: 10.1371/journal.pbio.1001704. Epub 2013 Nov 5. PLoS Biol. 2013. PMID: 24223520 Free PMC article.
A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation.
Dahlberg CI, He M, Visnes T, Torres ML, Cortizas EM, Verdun RE, Westerberg LS, Severinson E, Ström L. Dahlberg CI, et al. Among authors: westerberg ls. J Immunol. 2014 Nov 1;193(9):4732-8. doi: 10.4049/jimmunol.1401242. Epub 2014 Sep 24. J Immunol. 2014. PMID: 25252954 Free PMC article.
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies.
Dahlberg CI, Torres ML, Petersen SH, Baptista MA, Keszei M, Volpi S, Grasset EK, Karlsson MC, Walter JE, Snapper SB, Notarangelo LD, Westerberg LS. Dahlberg CI, et al. Among authors: westerberg ls. J Autoimmun. 2015 Aug;62:81-92. doi: 10.1016/j.jaut.2015.06.003. Epub 2015 Jul 2. J Autoimmun. 2015. PMID: 26143192 Free PMC article.
N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome.
Volpi S, Santori E, Abernethy K, Mizui M, Dahlberg CI, Recher M, Capuder K, Csizmadia E, Ryan D, Mathew D, Tsokos GC, Snapper S, Westerberg LS, Thrasher AJ, Candotti F, Notarangelo LD. Volpi S, et al. Among authors: westerberg ls. Blood. 2016 Jan 14;127(2):216-20. doi: 10.1182/blood-2015-05-643817. Epub 2015 Oct 14. Blood. 2016. PMID: 26468226 Free PMC article.
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, Worth AJ, Liedén A, Kuo IC, Wallin RP, Snapper SB, Eidsmo L, Scheynius A, Karlsson MC, Bouma G, Burns SO, Forsell MN, Thrasher AJ, Nylén S, Westerberg LS. Baptista MA, et al. Among authors: westerberg ls. Nat Commun. 2016 Jul 18;7:12175. doi: 10.1038/ncomms12175. Nat Commun. 2016. PMID: 27425374 Free PMC article.
IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.
Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. Kritikou JS, et al. Among authors: westerberg ls. Sci Rep. 2016 Aug 1;6:30636. doi: 10.1038/srep30636. Sci Rep. 2016. PMID: 27477778 Free PMC article.
90 results