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An evaluation of indirubin analogues as phosphorylase kinase inhibitors.
Begum J, Skamnaki VT, Moffatt C, Bischler N, Sarrou J, Skaltsounis AL, Leonidas DD, Oikonomakos NG, Hayes JM. Begum J, et al. Among authors: skaltsounis al. J Mol Graph Model. 2015 Sep;61:231-42. doi: 10.1016/j.jmgm.2015.07.010. Epub 2015 Aug 3. J Mol Graph Model. 2015. PMID: 26364215
6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis.
Xingi E, Smirlis D, Myrianthopoulos V, Magiatis P, Grant KM, Meijer L, Mikros E, Skaltsounis AL, Soteriadou K. Xingi E, et al. Among authors: skaltsounis al. Int J Parasitol. 2009 Oct;39(12):1289-303. doi: 10.1016/j.ijpara.2009.04.005. Epub 2009 May 13. Int J Parasitol. 2009. PMID: 19445946
Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined.
Hayes JM, Skamnaki VT, Archontis G, Lamprakis C, Sarrou J, Bischler N, Skaltsounis AL, Zographos SE, Oikonomakos NG. Hayes JM, et al. Among authors: skaltsounis al. Proteins. 2011 Mar;79(3):703-19. doi: 10.1002/prot.22890. Epub 2010 Dec 3. Proteins. 2011. PMID: 21287607
Glycogen phosphorylase inhibitors: a patent review (2008 - 2012).
Gaboriaud-Kolar N, Skaltsounis AL. Gaboriaud-Kolar N, et al. Among authors: skaltsounis al. Expert Opin Ther Pat. 2013 Aug;23(8):1017-32. doi: 10.1517/13543776.2013.794790. Epub 2013 Apr 30. Expert Opin Ther Pat. 2013. PMID: 23627914 Review.
An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3.
Efstathiou A, Gaboriaud-Kolar N, Smirlis D, Myrianthopoulos V, Vougogiannopoulou K, Alexandratos A, Kritsanida M, Mikros E, Soteriadou K, Skaltsounis AL. Efstathiou A, et al. Among authors: skaltsounis al. Parasit Vectors. 2014 May 20;7:234. doi: 10.1186/1756-3305-7-234. Parasit Vectors. 2014. PMID: 24886176 Free PMC article.
269 results