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An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.
Wilson NS, Yang B, Yang A, Loeser S, Marsters S, Lawrence D, Li Y, Pitti R, Totpal K, Yee S, Ross S, Vernes JM, Lu Y, Adams C, Offringa R, Kelley B, Hymowitz S, Daniel D, Meng G, Ashkenazi A. Wilson NS, et al. Among authors: offringa r. Cancer Cell. 2011 Jan 18;19(1):101-13. doi: 10.1016/j.ccr.2010.11.012. Cancer Cell. 2011. PMID: 21251615 Free article.
A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes.
Khandelwal N, Breinig M, Speck T, Michels T, Kreutzer C, Sorrentino A, Sharma AK, Umansky L, Conrad H, Poschke I, Offringa R, König R, Bernhard H, Machlenkin A, Boutros M, Beckhove P. Khandelwal N, et al. Among authors: offringa r. EMBO Mol Med. 2015 Apr;7(4):450-63. doi: 10.15252/emmm.201404414. EMBO Mol Med. 2015. PMID: 25691366 Free PMC article.
Cancer immunotherapy: exploiting neoepitopes.
Platten M, Offringa R. Platten M, et al. Among authors: offringa r. Cell Res. 2015 Aug;25(8):887-8. doi: 10.1038/cr.2015.66. Epub 2015 Jun 2. Cell Res. 2015. PMID: 26032267 Free PMC article.
Timed Ang2-Targeted Therapy Identifies the Angiopoietin-Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis.
Gengenbacher N, Singhal M, Mogler C, Hai L, Milde L, Pari AAA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG. Gengenbacher N, et al. Among authors: offringa r. Cancer Discov. 2021 Feb;11(2):424-445. doi: 10.1158/2159-8290.CD-20-0122. Epub 2020 Oct 26. Cancer Discov. 2021. PMID: 33106316
T cell-mediated elimination of cancer cells by blocking CEACAM6-CEACAM1 interaction.
Pinkert J, Boehm HH, Trautwein M, Doecke WD, Wessel F, Ge Y, Gutierrez EM, Carretero R, Freiberg C, Gritzan U, Luetke-Eversloh M, Golfier S, Von Ahsen O, Volpin V, Sorrentino A, Rathinasamy A, Xydia M, Lohmayer R, Sax J, Nur-Menevse A, Hussein A, Stamova S, Beckmann G, Glueck JM, Schoenfeld D, Weiske J, Zopf D, Offringa R, Kreft B, Beckhove P, Willuda J. Pinkert J, et al. Among authors: offringa r. Oncoimmunology. 2021 Dec 30;11(1):2008110. doi: 10.1080/2162402X.2021.2008110. eCollection 2022. Oncoimmunology. 2021. PMID: 35141051 Free PMC article.
265 results