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gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. Serneels L, et al. Among authors: de strooper b. Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19. Science. 2009. PMID: 19299585 Free PMC article.
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P. Jorissen E, et al. Among authors: de strooper b. J Neurosci. 2010 Apr 7;30(14):4833-44. doi: 10.1523/JNEUROSCI.5221-09.2010. J Neurosci. 2010. PMID: 20371803 Free PMC article.
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B. Kuperstein I, et al. Among authors: de strooper b. EMBO J. 2010 Oct 6;29(19):3408-20. doi: 10.1038/emboj.2010.211. Epub 2010 Sep 3. EMBO J. 2010. PMID: 20818335 Free PMC article.
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B. Zhou L, et al. Among authors: de strooper b. EMBO Mol Med. 2011 May;3(5):291-302. doi: 10.1002/emmm.201100138. Epub 2011 Apr 15. EMBO Mol Med. 2011. PMID: 21500352 Free PMC article.
Parkin interacts with Ambra1 to induce mitophagy.
Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W. Van Humbeeck C, et al. Among authors: de strooper b. J Neurosci. 2011 Jul 13;31(28):10249-61. doi: 10.1523/JNEUROSCI.1917-11.2011. J Neurosci. 2011. PMID: 21753002 Free PMC article.
An overlooked neurotoxic species in Alzheimer's disease.
Benilova I, De Strooper B. Benilova I, et al. Among authors: de strooper b. Nat Neurosci. 2011 Jul 26;14(8):949-50. doi: 10.1038/nn.2871. Nat Neurosci. 2011. PMID: 21792191 No abstract available.
396 results