Zheng J - Search Results

1

Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.

Dong Y, Li K, Xu Z, Ma H, Zheng J, Hu Z, He S, Wu Y, Sun Z, Luo L, Li J, Zhang H, Zhang X. Dong Y, et al. Among authors: zheng j. Bioorg Med Chem. 2015 Nov 1;23(21):6855-68. doi: 10.1016/j.bmc.2015.09.048. Epub 2015 Oct 1. Bioorg Med Chem. 2015. PMID: 26455655

2

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists.

Yang Z, Li X, Ma H, Zheng J, Zhen X, Zhang X. Yang Z, et al. Among authors: zheng j. Bioorg Med Chem Lett. 2014 Jan 1;24(1):152-5. doi: 10.1016/j.bmcl.2013.11.051. Epub 2013 Dec 1. Bioorg Med Chem Lett. 2014. PMID: 24332624

3

Scaffold hopping approach to a new series of smoothened antagonists.

Lu W, Geng D, Sun Z, Yang Z, Ma H, Zheng J, Zhang X. Lu W, et al. Among authors: zheng j. Bioorg Med Chem Lett. 2014 May 15;24(10):2300-4. doi: 10.1016/j.bmcl.2014.03.079. Epub 2014 Apr 3. Bioorg Med Chem Lett. 2014. PMID: 24726807

4

Optimization of 6-heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as potent adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Zheng J, Yang Z, Li X, Li L, Ma H, Wang M, Zhang H, Zhen X, Zhang X. Zheng J, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):674-82. doi: 10.1021/cn5000716. Epub 2014 Jun 23. ACS Chem Neurosci. 2014. PMID: 24922583 Free PMC article.

5

Design, synthesis, and structure--activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists.

Ma H, Lu W, Sun Z, Luo L, Geng D, Yang Z, Li E, Zheng J, Wang M, Zhang H, Yang S, Zhang X. Ma H, et al. Among authors: zheng j. Eur J Med Chem. 2015 Jan 7;89:721-32. doi: 10.1016/j.ejmech.2014.11.006. Epub 2014 Nov 4. Eur J Med Chem. 2015. PMID: 25462278

6

Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors.

Xu Z, Wu J, Zheng J, Ma H, Zhang H, Zhen X, Zheng LT, Zhang X. Xu Z, et al. Among authors: zheng lt, zheng j. Int Immunopharmacol. 2015 Apr;25(2):528-37. doi: 10.1016/j.intimp.2015.02.033. Epub 2015 Mar 10. Int Immunopharmacol. 2015. PMID: 25765352

7

Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors.

Yang Z, Ma H, Sun Z, Luo L, Tian S, Zheng J, Zhang X. Yang Z, et al. Among authors: zheng j. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3665-70. doi: 10.1016/j.bmcl.2015.06.049. Epub 2015 Jun 18. Bioorg Med Chem Lett. 2015. PMID: 26119500

8

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system.

Xu Z, Li J, Wu Y, Sun Z, Luo L, Hu Z, He S, Zheng J, Zhang H, Zhang X. Xu Z, et al. Among authors: zheng j. Eur J Med Chem. 2016 Jan 27;108:154-165. doi: 10.1016/j.ejmech.2015.11.026. Epub 2015 Nov 22. Eur J Med Chem. 2016. PMID: 26647303

9

Metabolic Activation of Rhein: Insights into the Potential Toxicity Induced by Rhein-Containing Herbs.

Yuan Y, Zheng J, Wang M, Li Y, Ruan J, Zhang H. Yuan Y, et al. Among authors: zheng j. J Agric Food Chem. 2016 Jul 20;64(28):5742-50. doi: 10.1021/acs.jafc.6b01872. Epub 2016 Jul 12. J Agric Food Chem. 2016. PMID: 27362917

10

Identification of a New Series of Potent Adenosine A_2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson's Disease.

Yang Z, Li L, Zheng J, Ma H, Tian S, Li J, Zhang H, Zhen X, Zhang X. Yang Z, et al. Among authors: zheng j. ACS Chem Neurosci. 2016 Nov 16;7(11):1575-1584. doi: 10.1021/acschemneuro.6b00218. Epub 2016 Sep 9. ACS Chem Neurosci. 2016. PMID: 27569066

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