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Current and Future Chemotherapy for Chagas Disease.
Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. Gaspar L, et al. Among authors: smith tk. Curr Med Chem. 2015;22(37):4293-312. doi: 10.2174/0929867322666151015120804. Curr Med Chem. 2015. PMID: 26477622 Free article. Review.
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
Gaspar L, Coron RP, KongThoo Lin P, Costa DM, Perez-Cabezas B, Tavares J, Roura-Ferrer M, Ramos I, Ronin C, Major LL, Ciesielski F, Pemberton IK, MacDougall J, Ciapetti P, Smith TK, Cordeiro-da-Silva A. Gaspar L, et al. Among authors: smith tk. PLoS Negl Trop Dis. 2018 Jan 22;12(1):e0006180. doi: 10.1371/journal.pntd.0006180. eCollection 2018 Jan. PLoS Negl Trop Dis. 2018. PMID: 29357372 Free PMC article.
Direct and indirect approaches to identify drug modes of action.
Tulloch LB, Menzies SK, Coron RP, Roberts MD, Florence GJ, Smith TK. Tulloch LB, et al. Among authors: smith tk. IUBMB Life. 2018 Jan;70(1):9-22. doi: 10.1002/iub.1697. Epub 2017 Dec 6. IUBMB Life. 2018. PMID: 29210173 Free article. Review.
Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target.
Dickie EA, Ronin C, Sá M, Ciesielski F, Trouche N, Tavares J, Santarem N, Major LL, Pemberton IK, MacDougall J, Smith TK, Cordeiro-da-Silva A, Ciapetti P. Dickie EA, et al. Among authors: smith tk. Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0189220. doi: 10.1128/AAC.01892-20. Epub 2021 Jun 17. Antimicrob Agents Chemother. 2021. PMID: 33875438 Free PMC article.
Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.
Seixas JD, Luengo-Arratta SA, Diaz R, Saldivia M, Rojas-Barros DI, Manzano P, Gonzalez S, Berlanga M, Smith TK, Navarro M, Pollastri MP. Seixas JD, et al. Among authors: smith tk. J Med Chem. 2014 Jun 12;57(11):4834-48. doi: 10.1021/jm500361r. Epub 2014 May 21. J Med Chem. 2014. PMID: 24805946 Free PMC article.
442 results