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Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes.
Leung MC, Phuong J, Baker NC, Sipes NS, Klinefelter GR, Martin MT, McLaurin KW, Setzer RW, Darney SP, Judson RS, Knudsen TB. Leung MC, et al. Among authors: sipes ns. Environ Health Perspect. 2016 Jul;124(7):1050-61. doi: 10.1289/ehp.1510385. Epub 2015 Dec 11. Environ Health Perspect. 2016. PMID: 26662846 Free PMC article.
We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targets to include retinoic acid signaling, vascular remodeling proteins, G-protein coupled receptors (GPCRs), and cytochrome P450s. CITATION: L …
We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targ …
Environmental impact on vascular development predicted by high-throughput screening.
Kleinstreuer NC, Judson RS, Reif DM, Sipes NS, Singh AV, Chandler KJ, Dewoskin R, Dix DJ, Kavlock RJ, Knudsen TB. Kleinstreuer NC, et al. Among authors: sipes ns. Environ Health Perspect. 2011 Nov;119(11):1596-603. doi: 10.1289/ehp.1103412. Epub 2011 Jul 25. Environ Health Perspect. 2011. PMID: 21788198 Free PMC article.
Predictive models and computational toxicology.
Knudsen T, Martin M, Chandler K, Kleinstreuer N, Judson R, Sipes N. Knudsen T, et al. Methods Mol Biol. 2013;947:343-74. doi: 10.1007/978-1-62703-131-8_26. Methods Mol Biol. 2013. PMID: 23138916 Review.
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
Knudsen TB, Houck KA, Sipes NS, Singh AV, Judson RS, Martin MT, Weissman A, Kleinstreuer NC, Mortensen HM, Reif DM, Rabinowitz JR, Setzer RW, Richard AM, Dix DJ, Kavlock RJ. Knudsen TB, et al. Among authors: sipes ns. Toxicology. 2011 Mar 28;282(1-2):1-15. doi: 10.1016/j.tox.2010.12.010. Epub 2011 Jan 18. Toxicology. 2011. PMID: 21251949
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.
Wambaugh JF, Hughes MF, Ring CL, MacMillan DK, Ford J, Fennell TR, Black SR, Snyder RW, Sipes NS, Wetmore BA, Westerhout J, Setzer RW, Pearce RG, Simmons JE, Thomas RS. Wambaugh JF, et al. Among authors: sipes ns. Toxicol Sci. 2018 May 1;163(1):152-169. doi: 10.1093/toxsci/kfy020. Toxicol Sci. 2018. PMID: 29385628 Free PMC article.
51 results