Jirgensons A - Search Results

1

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.

Rasina D, Otikovs M, Leitans J, Recacha R, Borysov OV, Kanepe-Lapsa I, Domraceva I, Pantelejevs T, Tars K, Blackman MJ, Jaudzems K, Jirgensons A. Rasina D, et al. Among authors: jirgensons a. J Med Chem. 2016 Jan 14;59(1):374-87. doi: 10.1021/acs.jmedchem.5b01558. Epub 2015 Dec 23. J Med Chem. 2016. PMID: 26670264

2

Synthesis and structure-affinity relationships of 1,3, 5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site.

Jirgensons A, Kauss V, Kalvinsh I, Gold MR, Danysz W, Parsons CG, Quack G. Jirgensons A, et al. Eur J Med Chem. 2000 Jun;35(6):555-65. doi: 10.1016/s0223-5234(00)00153-7. Eur J Med Chem. 2000. PMID: 10906408

3

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ. Withers-Martinez C, et al. Among authors: jirgensons a. Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27. Int J Parasitol. 2012. PMID: 22543039 Free PMC article.

4

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.

Jaudzems K, Tars K, Maurops G, Ivdra N, Otikovs M, Leitans J, Kanepe-Lapsa I, Domraceva I, Mutule I, Trapencieris P, Blackman MJ, Jirgensons A. Jaudzems K, et al. Among authors: jirgensons a. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7. doi: 10.1021/ml4004952. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900843 Free PMC article.

5

Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.

Kher SS, Penzo M, Fulle S, Finn PW, Blackman MJ, Jirgensons A. Kher SS, et al. Among authors: jirgensons a. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4486-4489. doi: 10.1016/j.bmcl.2014.07.086. Epub 2014 Aug 7. Bioorg Med Chem Lett. 2014. PMID: 25129616

6

2-Vinyl Threoninol Derivatives via Acid-Catalyzed Allylic Substitution of Bisimidates.

Kumar V, Klimovica K, Rasina D, Jirgensons A. Kumar V, et al. Among authors: jirgensons a. J Org Chem. 2015 Jun 5;80(11):5934-43. doi: 10.1021/acs.joc.5b00529. Epub 2015 May 18. J Org Chem. 2015. PMID: 25941908

7

Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.

Recacha R, Leitans J, Akopjana I, Aprupe L, Trapencieris P, Jaudzems K, Jirgensons A, Tars K. Recacha R, et al. Among authors: jirgensons a. Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1531-9. doi: 10.1107/S2053230X15022049. Epub 2015 Nov 27. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26625296 Free PMC article.

8

A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus.

Gupta A, Monteferrante C, Rasina D, Leitis G, Randall CP, Tomlinson JH, Jirgensons A, Goessens WH, Hays JP, O'Neill AJ. Gupta A, et al. Among authors: jirgensons a. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21. doi: 10.1128/AAC.02940-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26976861 Free PMC article.

9

Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme.

Randall CP, Rasina D, Jirgensons A, O'Neill AJ. Randall CP, et al. Among authors: jirgensons a. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6359-61. doi: 10.1128/AAC.00674-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27431224 Free PMC article.

10

Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.

Recacha R, Jaudzems K, Akopjana I, Jirgensons A, Tars K. Recacha R, et al. Among authors: jirgensons a. Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):659-66. doi: 10.1107/S2053230X16011663. Epub 2016 Aug 9. Acta Crystallogr F Struct Biol Commun. 2016. PMID: 27599854 Free PMC article.

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