Kadow JF - Search Results

1

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

Hewawasam P, Tu Y, Gao M, Hanumegowda U, Knipe J, Lemm JA, Parker DD, Rigat KL, Roberts SB, Meanwell NA, Kadow JF. Hewawasam P, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2016 Feb 1;26(3):936-940. doi: 10.1016/j.bmcl.2015.12.058. Epub 2015 Dec 19. Bioorg Med Chem Lett. 2016. PMID: 26747393

2

Structure-activity relationships study at the 3'-N position of paclitaxel. Part 2: synthesis and biological evaluation of 3'-N-thiourea- and 3'-N-thiocarbamate-bearing paclitaxel analogues.

Xue M, Long BH, Fairchild C, Johnston K, Rose WC, Kadow JF, Vyas DM, Chen SH. Xue M, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2000 Jun 19;10(12):1327-31. doi: 10.1016/s0960-894x(00)00242-0. Bioorg Med Chem Lett. 2000. PMID: 10890157

3

Synthesis of metabolically blocked paclitaxel analogues.

Wittman MD, Altstadt TJ, Fairchild C, Hansel S, Johnston K, Kadow JF, Long BH, Rose WC, Vyas DM, Wu MJ, Zoeckler ME. Wittman MD, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2001 Mar 26;11(6):809-10. doi: 10.1016/s0960-894x(01)00066-x. Bioorg Med Chem Lett. 2001. PMID: 11277525

4

Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids.

Wittman MD, Kadow JF, Vyas DM, Lee FL, Rose WC, Long BH, Fairchild C, Johnston K. Wittman MD, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2001 Mar 26;11(6):811-4. doi: 10.1016/s0960-894x(01)00067-1. Bioorg Med Chem Lett. 2001. PMID: 11277526

5

Synthesis of a novel C-10 spiro-epoxide of paclitaxel.

Walker MA, Johnson TD, Huang S, Vyas DM, Kadow JF. Walker MA, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1683-5. doi: 10.1016/s0960-894x(01)00280-3. Bioorg Med Chem Lett. 2001. PMID: 11425537

6

Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.

Altstadt TJ, Fairchild CR, Golik J, Johnston KA, Kadow JF, Lee FY, Long BH, Rose WC, Vyas DM, Wong H, Wu MJ, Wittman MD. Altstadt TJ, et al. Among authors: kadow jf. J Med Chem. 2001 Dec 20;44(26):4577-83. doi: 10.1021/jm0102607. J Med Chem. 2001. PMID: 11741476

7

A strategy for the synthesis of aryl alpha-ketoamides based upon the acylation of anions derived from cyanomethylamines followed by oxidative cleavage.

Yang Z, Zhang Z, Meanwell NA, Kadow JF, Wang T. Yang Z, et al. Among authors: kadow jf. Org Lett. 2002 Apr 4;4(7):1103-5. doi: 10.1021/ol010297l. Org Lett. 2002. PMID: 11922793

8

A general method for the preparation of 4- and 6-azaindoles.

Zhang Z, Yang Z, Meanwell NA, Kadow JF, Wang T. Zhang Z, et al. Among authors: kadow jf. J Org Chem. 2002 Apr 5;67(7):2345-7. doi: 10.1021/jo0111614. J Org Chem. 2002. PMID: 11925251

9

An effective procedure for the acylation of azaindoles at C-3.

Zhang Z, Yang Z, Wong H, Zhu J, Meanwell NA, Kadow JF, Wang T. Zhang Z, et al. Among authors: kadow jf. J Org Chem. 2002 Aug 23;67(17):6226-7. doi: 10.1021/jo020135i. J Org Chem. 2002. PMID: 12182666

10

Inhibitors of the entry of HIV into host cells.

Meanwell NA, Kadow JF. Meanwell NA, et al. Among authors: kadow jf. Curr Opin Drug Discov Devel. 2003 Jul;6(4):451-61. Curr Opin Drug Discov Devel. 2003. PMID: 12951808 Review.

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