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Page 1
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC. Mullarky E, et al. Among authors: beheshti zavareh r. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831078 Free PMC article.
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Holt MC, et al. Among authors: beheshti zavareh r. Biochemistry. 2018 Nov 27;57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12. Biochemistry. 2018. PMID: 30365304 Free PMC article.
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD. Xu GW, et al. Among authors: beheshti zavareh r. Blood. 2010 Mar 18;115(11):2251-9. doi: 10.1182/blood-2009-07-231191. Epub 2010 Jan 14. Blood. 2010. PMID: 20075161 Free PMC article.
Suppression of cancer progression by MGAT1 shRNA knockdown.
Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW. Beheshti Zavareh R, et al. PLoS One. 2012;7(9):e43721. doi: 10.1371/journal.pone.0043721. Epub 2012 Sep 5. PLoS One. 2012. PMID: 22957033 Free PMC article.
Cyproheptadine displays preclinical activity in myeloma and leukemia.
Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Beheshti Zavareh R, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD. Mao X, et al. Among authors: beheshti zavareh r. Blood. 2008 Aug 1;112(3):760-9. doi: 10.1182/blood-2008-02-142687. Epub 2008 May 23. Blood. 2008. PMID: 18502826 Free article.
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.
Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD. Spagnuolo PA, et al. Among authors: beheshti zavareh r. Blood. 2010 Jun 10;115(23):4824-33. doi: 10.1182/blood-2009-09-243055. Epub 2010 Mar 26. Blood. 2010. PMID: 20348394 Free article.
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.
Simpson CD, Mawji IA, Anyiwe K, Williams MA, Wang X, Venugopal AL, Gronda M, Hurren R, Cheng S, Serra S, Beheshti Zavareh R, Datti A, Wrana JL, Ezzat S, Schimmer AD. Simpson CD, et al. Among authors: beheshti zavareh r. Cancer Res. 2009 Apr 1;69(7):2739-47. doi: 10.1158/0008-5472.CAN-08-2530. Epub 2009 Mar 17. Cancer Res. 2009. PMID: 19293189
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD. Beheshti Zavareh R, et al. Cancer Res. 2008 Aug 15;68(16):6688-97. doi: 10.1158/0008-5472.CAN-07-6833. Cancer Res. 2008. PMID: 18701493
Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population.
Percy M, Moalem S, Garcia A, Somerville MJ, Hicks M, Andrews D, Azad A, Schwarz P, Beheshti Zavareh R, Birkan R, Choo C, Chow V, Dhaliwal S, Duda V, Kupferschmidt AL, Lam K, Lightman D, Machalek K, Mar W, Nguyen F, Rytwinski PJ, Svara E, Tran M, Wheeler K, Yeung L, Zanibbi K, Zener R, Ziraldo M, Freedman M. Percy M, et al. Among authors: beheshti zavareh r. J Alzheimers Dis. 2008 May;14(1):69-84. doi: 10.3233/jad-2008-14107. J Alzheimers Dis. 2008. PMID: 18525129