Flanagan JU - Search Results

1

One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?

Glass M, Govindpani K, Furkert DP, Hurst DP, Reggio PH, Flanagan JU. Glass M, et al. Among authors: flanagan ju. Trends Pharmacol Sci. 2016 May;37(5):353-363. doi: 10.1016/j.tips.2016.01.010. Epub 2016 Feb 22. Trends Pharmacol Sci. 2016. PMID: 26917061 Review.

2

Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development.

Archbold JK, Flanagan JU, Watkins HA, Gingell JJ, Hay DL. Archbold JK, et al. Among authors: flanagan ju. Trends Pharmacol Sci. 2011 Oct;32(10):591-600. doi: 10.1016/j.tips.2011.05.007. Epub 2011 Jun 29. Trends Pharmacol Sci. 2011. PMID: 21722971 Review.

3

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.

Yosaatmadja Y, Silva S, Dickson JM, Patterson AV, Smaill JB, Flanagan JU, McKeage MJ, Squire CJ. Yosaatmadja Y, et al. Among authors: flanagan ju. J Struct Biol. 2015 Dec;192(3):539-544. doi: 10.1016/j.jsb.2015.10.018. Epub 2015 Nov 2. J Struct Biol. 2015. PMID: 26522274

4

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

Gong GQ, Kendall JD, Dickson JMJ, Rewcastle GW, Buchanan CM, Denny WA, Shepherd PR, Flanagan JU. Gong GQ, et al. Among authors: flanagan ju. Biochem J. 2017 Jun 26;474(13):2261-2276. doi: 10.1042/BCJ20161098. Biochem J. 2017. PMID: 28526744

5

Computational Prediction of Amino Acids Governing Protein-Membrane Interaction for the PIP₃ Cell Signaling System.

Irvine WA, Flanagan JU, Allison JR. Irvine WA, et al. Among authors: flanagan ju. Structure. 2019 Feb 5;27(2):371-380.e3. doi: 10.1016/j.str.2018.10.014. Epub 2018 Dec 6. Structure. 2019. PMID: 30528597 Free article.

6

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.

Hendrikse ER, Liew LP, Bower RL, Bonnet M, Jamaluddin MA, Prodan N, Richards KD, Walker CS, Pairaudeau G, Smith DM, Rujan RM, Sudra R, Reynolds CA, Booe JM, Pioszak AA, Flanagan JU, Hay MP, Hay DL. Hendrikse ER, et al. Among authors: flanagan ju. ACS Pharmacol Transl Sci. 2020 Mar 12;3(2):305-320. doi: 10.1021/acsptsci.9b00108. eCollection 2020 Apr 10. ACS Pharmacol Transl Sci. 2020. PMID: 32296770 Free PMC article.

7

Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation.

Denny WA, Flanagan JU. Denny WA, et al. Among authors: flanagan ju. Biomolecules. 2021 Nov 10;11(11):1671. doi: 10.3390/biom11111671. Biomolecules. 2021. PMID: 34827669 Free PMC article.

8

SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.

Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. Bonnet M, et al. Among authors: flanagan ju. Bioorg Med Chem. 2011 Jun 1;19(11):3347-56. doi: 10.1016/j.bmc.2011.04.042. Epub 2011 Apr 24. Bioorg Med Chem. 2011. PMID: 21561782 Free PMC article.

9

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Rewcastle GW, Gamage SA, Flanagan JU, Kendall JD, Denny WA, Baguley BC, Buchanan CM, Chao M, Kestell P, Kolekar S, Lee WJ, Lill CL, Malik A, Singh R, Jamieson SM, Shepherd PR. Rewcastle GW, et al. Among authors: flanagan ju. Eur J Med Chem. 2013 Jun;64:137-47. doi: 10.1016/j.ejmech.2013.03.038. Epub 2013 Apr 6. Eur J Med Chem. 2013. PMID: 23644197

10

Targeting growth hormone function: strategies and therapeutic applications.

Lu M, Flanagan JU, Langley RJ, Hay MP, Perry JK. Lu M, et al. Among authors: flanagan ju. Signal Transduct Target Ther. 2019 Feb 8;4:3. doi: 10.1038/s41392-019-0036-y. eCollection 2019. Signal Transduct Target Ther. 2019. PMID: 30775002 Free PMC article. Review.

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