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Vulnerability of newly synthesized proteins to proteostasis stress.
Xu G, Pattamatta A, Hildago R, Pace MC, Brown H, Borchelt DR. Xu G, et al. Among authors: borchelt dr. J Cell Sci. 2016 May 1;129(9):1892-901. doi: 10.1242/jcs.176479. Epub 2016 Mar 29. J Cell Sci. 2016. PMID: 27026526 Free PMC article.
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Tebbenkamp AT, et al. Among authors: borchelt dr. Hum Mol Genet. 2011 Jul 15;20(14):2770-82. doi: 10.1093/hmg/ddr176. Epub 2011 Apr 22. Hum Mol Genet. 2011. PMID: 21515588 Free PMC article.
A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo.
Prudencio M, Lelie H, Brown HH, Whitelegge JP, Valentine JS, Borchelt DR. Prudencio M, et al. Among authors: borchelt dr. J Neurochem. 2012 May;121(3):475-85. doi: 10.1111/j.1471-4159.2012.07690.x. Epub 2012 Mar 20. J Neurochem. 2012. PMID: 22332887 Free PMC article.
235 results