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Synthesis and evaluation of a potent, well-balanced EP2/EP3 dual agonist.
Kinoshita A, Higashino M, Yoshida K, Aratani Y, Kakuuchi A, Hanada K, Takeda H, Naganawa A, Matsuya H, Ohmoto K. Kinoshita A, et al. Among authors: takeda h. Bioorg Med Chem. 2018 Jan 1;26(1):200-214. doi: 10.1016/j.bmc.2017.11.035. Epub 2017 Nov 24. Bioorg Med Chem. 2018. PMID: 29203142
Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF₁) receptor antagonists.
Saito T, Obitsu T, Kohno H, Sugimoto I, Matsushita T, Nishiyama T, Hirota T, Takeda H, Matsumura N, Ueno S, Kishi A, Kagamiishi Y, Nakai H, Takaoka Y. Saito T, et al. Among authors: takeda h. Bioorg Med Chem. 2012 Jan 15;20(2):1122-38. doi: 10.1016/j.bmc.2011.11.015. Epub 2011 Dec 3. Bioorg Med Chem. 2012. PMID: 22196514
PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H. Sekine H, et al. Among authors: takeda h. Nat Metab. 2024 May 31. doi: 10.1038/s42255-024-01053-4. Online ahead of print. Nat Metab. 2024. PMID: 38822028
Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis.
Takahashi K, Tsuji M, Nakagawasai O, Miyagawa K, Kurokawa K, Mochida-Saito A, Iwasa M, Iwasa H, Suzuki S, Takeda H, Tadano T. Takahashi K, et al. Among authors: takeda h. Sci Rep. 2024 May 21;14(1):11519. doi: 10.1038/s41598-024-62309-3. Sci Rep. 2024. PMID: 38769131 Free PMC article.
Effect of preceding drug therapy on the renal and cardiovascular outcomes of combined sodium-glucose cotransporter-2 inhibitor and glucagon-like peptide-1 receptor agonist treatment in patients with type 2 diabetes and chronic kidney disease.
RECAP study group; Tsukamoto S, Kobayashi K, Toyoda M, Tone A, Kawanami D, Suzuki D, Tsuriya D, Machimura H, Shimura H, Wakui H, Takeda H, Yokomizo H, Takeshita K, Chin K, Kanasaki K, Miyauchi M, Saburi M, Morita M, Yomota M, Kimura M, Hatori N, Nakajima S, Ito S, Murata T, Matsushita T, Furuki T, Hashimoto T, Umezono T, Muta Y, Takashi Y, Tamura K. RECAP study group, et al. Among authors: takeda h. Diabetes Obes Metab. 2024 May 19. doi: 10.1111/dom.15652. Online ahead of print. Diabetes Obes Metab. 2024. PMID: 38764356
snRNAs from Radical Prostatectomy Specimens Have the Potential to Serve as Prognostic Factors for Clinical Recurrence after Biochemical Recurrence in Patients with High-Risk Prostate Cancer.
Mikami H, Noguchi S, Akatsuka J, Hasegawa H, Obayashi K, Takeda H, Endo Y, Toyama Y, Takei H, Kimura G, Kondo Y, Takizawa T. Mikami H, et al. Among authors: takeda h. Cancers (Basel). 2024 May 1;16(9):1757. doi: 10.3390/cancers16091757. Cancers (Basel). 2024. PMID: 38730709 Free PMC article.
2,475 results