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Targeting caspase-3 as dual therapeutic benefits by RNAi facilitating brain-targeted nanoparticles in a rat model of Parkinson's disease.
Liu Y, Guo Y, An S, Kuang Y, He X, Ma H, Li J, Lu J, Zhang N, Jiang C. Liu Y, et al. Among authors: an s. PLoS One. 2013 May 13;8(5):e62905. doi: 10.1371/journal.pone.0062905. Print 2013. PLoS One. 2013. PMID: 23675438 Free PMC article.
The activation of caspase-3 is an important hallmark in Parkinson's disease. It could induce neuron death by apoptosis and microglia activation by inflammation. As a result, inhibition the activation of caspase-3 would exert synergistic dual effect in brain in order …
The activation of caspase-3 is an important hallmark in Parkinson's disease. It could induce neuron death by apoptosis and mic …
Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy.
Shao K, Ding N, Huang S, Ren S, Zhang Y, Kuang Y, Guo Y, Ma H, An S, Li Y, Jiang C. Shao K, et al. Among authors: an s. ACS Nano. 2014 Feb 25;8(2):1191-203. doi: 10.1021/nn406285x. Epub 2014 Jan 13. ACS Nano. 2014. PMID: 24397286
This nanodevice was fabricated with a cross-linker, containing disulfide linkage to form an inner cellular microenvironment-responsive "-S-S-" barrier, which could shield the entrapped drug leaking in blood circulation. ...
This nanodevice was fabricated with a cross-linker, containing disulfide linkage to form an inner cellular microenvironment-responsiv …
4,038 results