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BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.
van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, Joosten SA, van Harmelen V, de Winther MPJ, Lütjohann D, Lutgens E, Boon MR, Riksen NP, Rensen PCN, Berbée JFP. van Dam AD, et al. Among authors: de winther mpj. Atherosclerosis. 2016 Aug;251:6-14. doi: 10.1016/j.atherosclerosis.2016.05.031. Epub 2016 May 19. Atherosclerosis. 2016. PMID: 27232458 Free article.
Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.
de Winther MP, van Dijk KW, van Vlijmen BJ, Gijbels MJ, Heus JJ, Wijers ER, van den Bos AC, Breuer M, Frants RR, Havekes LM, Hofker MH. de Winther MP, et al. Atherosclerosis. 1999 Dec;147(2):339-47. doi: 10.1016/s0021-9150(99)00204-x. Atherosclerosis. 1999. PMID: 10559520
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation.
Lutgens E, Lutgens SP, Faber BC, Heeneman S, Gijbels MM, de Winther MP, Frederik P, van der Made I, Daugherty A, Sijbers AM, Fisher A, Long CJ, Saftig P, Black D, Daemen MJ, Cleutjens KB. Lutgens E, et al. Circulation. 2006 Jan 3;113(1):98-107. doi: 10.1161/CIRCULATIONAHA.105.561449. Epub 2005 Dec 19. Circulation. 2006. PMID: 16365196
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile.
Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, Seijkens T, Engel D, Cleutjens J, Keller AM, Naik SH, Boon L, Oufella HA, Mallat Z, Ahonen CL, Noelle RJ, de Winther MP, Daemen MJ, Biessen EA, Weber C. Lutgens E, et al. J Exp Med. 2010 Feb 15;207(2):391-404. doi: 10.1084/jem.20091293. Epub 2010 Jan 25. J Exp Med. 2010. PMID: 20100871 Free PMC article.
197 results