Thomas CJ - Search Results

1

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.

Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE 3rd, Thomas CJ. Kasbekar M, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7503-8. doi: 10.1073/pnas.1600630113. Epub 2016 Jun 20. Proc Natl Acad Sci U S A. 2016. PMID: 27325754 Free PMC article.

2

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor.

Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Titus S, et al. Among authors: thomas cj. J Biomol Screen. 2008 Feb;13(2):120-7. doi: 10.1177/1087057107313786. Epub 2008 Jan 23. J Biomol Screen. 2008. PMID: 18216391 Free PMC article.

3

Selective targeting of ITK blocks multiple steps of HIV replication.

Readinger JA, Schiralli GM, Jiang JK, Thomas CJ, August A, Henderson AJ, Schwartzberg PL. Readinger JA, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6684-9. doi: 10.1073/pnas.0709659105. Epub 2008 Apr 28. Proc Natl Acad Sci U S A. 2008. PMID: 18443296 Free PMC article.

4

Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants.

Marinello J, Marchand C, Mott BT, Bain A, Thomas CJ, Pommier Y. Marinello J, et al. Among authors: thomas cj. Biochemistry. 2008 Sep 9;47(36):9345-54. doi: 10.1021/bi800791q. Epub 2008 Aug 15. Biochemistry. 2008. PMID: 18702518 Free PMC article.

5

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.

Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Neumann S, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6. doi: 10.1073/pnas.0904506106. Epub 2009 Jul 10. Proc Natl Acad Sci U S A. 2009. PMID: 19592511 Free PMC article.

6

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan JJ, Inglese J, Austin CP, Misteli T, Auld DS, Thomas CJ. Mott BT, et al. Among authors: thomas cj. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6700-5. doi: 10.1016/j.bmcl.2009.09.121. Epub 2009 Oct 3. Bioorg Med Chem Lett. 2009. PMID: 19837585 Free PMC article.

7

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Jadhav A, et al. Among authors: thomas cj. J Med Chem. 2010 Jan 14;53(1):37-51. doi: 10.1021/jm901070c. J Med Chem. 2010. PMID: 19908840 Free PMC article.

8

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. Mott BT, et al. Among authors: thomas cj. J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a. J Med Chem. 2010. PMID: 19908842 Free PMC article.

9

Comparison of bioluminescent kinase assays using substrate depletion and product formation.

Tanega C, Shen M, Mott BT, Thomas CJ, MacArthur R, Inglese J, Auld DS. Tanega C, et al. Among authors: thomas cj. Assay Drug Dev Technol. 2009 Dec;7(6):606-14. doi: 10.1089/adt.2009.0230. Assay Drug Dev Technol. 2009. PMID: 20059377 Free PMC article.

10

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

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