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Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists.
Kiyotsuka Y, Shimada K, Kobayashi S, Suzuki M, Akiu M, Asano M, Sogawa Y, Hara T, Konishi M, Abe-Ohya R, Izumi M, Nagai Y, Yoshida K, Abe Y, Takamori H, Takahashi H. Kiyotsuka Y, et al. Among authors: kobayashi s. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4205-10. doi: 10.1016/j.bmcl.2016.07.056. Epub 2016 Jul 25. Bioorg Med Chem Lett. 2016. PMID: 27491709
Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.
Matsufuji T, Shimada K, Kobayashi S, Ichikawa M, Kawamura A, Fujimoto T, Arita T, Hara T, Konishi M, Abe-Ohya R, Izumi M, Sogawa Y, Nagai Y, Yoshida K, Abe Y, Kimura T, Takahashi H. Matsufuji T, et al. Among authors: kobayashi s. Bioorg Med Chem. 2015 Jan 1;23(1):89-104. doi: 10.1016/j.bmc.2014.11.018. Epub 2014 Nov 21. Bioorg Med Chem. 2015. PMID: 25497965
Design, synthesis, and biological activity of novel factor Xa inhibitors: improving metabolic stability by S1 and S4 ligand modification.
Komoriya S, Kobayashi S, Osanai K, Yoshino T, Nagata T, Haginoya N, Nakamoto Y, Mochizuki A, Nagahara T, Suzuki M, Shimada T, Watanabe K, Isobe Y, Furugoori T. Komoriya S, et al. Among authors: kobayashi s. Bioorg Med Chem. 2006 Mar 1;14(5):1309-30. doi: 10.1016/j.bmc.2005.09.056. Epub 2005 Nov 2. Bioorg Med Chem. 2006. PMID: 16263291
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Yoshikawa K, Kobayashi S, Nakamoto Y, Haginoya N, Komoriya S, Yoshino T, Nagata T, Mochizuki A, Watanabe K, Suzuki M, Kanno H, Ohta T. Yoshikawa K, et al. Among authors: kobayashi s. Bioorg Med Chem. 2009 Dec 15;17(24):8221-33. doi: 10.1016/j.bmc.2009.10.024. Epub 2009 Oct 17. Bioorg Med Chem. 2009. PMID: 19900814
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.
Yoshikawa K, Yokomizo A, Naito H, Haginoya N, Kobayashi S, Yoshino T, Nagata T, Mochizuki A, Osanai K, Watanabe K, Kanno H, Ohta T. Yoshikawa K, et al. Among authors: kobayashi s. Bioorg Med Chem. 2009 Dec 15;17(24):8206-20. doi: 10.1016/j.bmc.2009.10.023. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884015
9,965 results