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Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists.
Kiyotsuka Y, Shimada K, Kobayashi S, Suzuki M, Akiu M, Asano M, Sogawa Y, Hara T, Konishi M, Abe-Ohya R, Izumi M, Nagai Y, Yoshida K, Abe Y, Takamori H, Takahashi H. Kiyotsuka Y, et al. Among authors: shimada k. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4205-10. doi: 10.1016/j.bmcl.2016.07.056. Epub 2016 Jul 25. Bioorg Med Chem Lett. 2016. PMID: 27491709
Potent and selective cathepsin K inhibitors.
Shinozuka T, Shimada K, Matsui S, Yamane T, Ama M, Fukuda T, Taki M, Takeda Y, Otsuka E, Yamato M, Mochizuki S, Ohhata K, Naito S. Shinozuka T, et al. Among authors: shimada k. Bioorg Med Chem. 2006 Oct 15;14(20):6789-806. doi: 10.1016/j.bmc.2006.06.032. Epub 2006 Jul 13. Bioorg Med Chem. 2006. PMID: 16842999
Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.
Matsufuji T, Shimada K, Kobayashi S, Ichikawa M, Kawamura A, Fujimoto T, Arita T, Hara T, Konishi M, Abe-Ohya R, Izumi M, Sogawa Y, Nagai Y, Yoshida K, Abe Y, Kimura T, Takahashi H. Matsufuji T, et al. Among authors: shimada k. Bioorg Med Chem. 2015 Jan 1;23(1):89-104. doi: 10.1016/j.bmc.2014.11.018. Epub 2014 Nov 21. Bioorg Med Chem. 2015. PMID: 25497965
Alkylsulfanyl analogs as potent α2δ ligands.
Shimada K, Ohata Y, Kobayashi J, Onishi Y, Kawamura A, Domon Y, Arakawa N, Inoue T, Kitano Y, Matsuda F, Abe Y, Deguchi T. Shimada K, et al. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2000-2002. doi: 10.1016/j.bmcl.2018.05.006. Epub 2018 May 4. Bioorg Med Chem Lett. 2018. PMID: 29752183
Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: shimada k. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. doi: 10.1016/j.bmc.2018.09.005. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30220602
Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: shimada k. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30241907
4,633 results