Melnick AM - Search Results

1

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.

Bunting KL, Soong TD, Singh R, Jiang Y, Béguelin W, Poloway DW, Swed BL, Hatzi K, Reisacher W, Teater M, Elemento O, Melnick AM. Bunting KL, et al. Among authors: melnick am. Immunity. 2016 Sep 20;45(3):497-512. doi: 10.1016/j.immuni.2016.08.012. Epub 2016 Sep 13. Immunity. 2016. PMID: 27637145 Free PMC article.

2

B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma.

Ci W, Polo JM, Melnick A. Ci W, et al. Curr Opin Hematol. 2008 Jul;15(4):381-90. doi: 10.1097/MOH.0b013e328302c7df. Curr Opin Hematol. 2008. PMID: 18536578 Free PMC article. Review.

3

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo.

Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy SF, Melnick A. Cerchietti LC, et al. Blood. 2009 Apr 9;113(15):3397-405. doi: 10.1182/blood-2008-07-168773. Epub 2008 Oct 16. Blood. 2009. PMID: 18927431 Free PMC article.

4

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A. Ci W, et al. Blood. 2009 May 28;113(22):5536-48. doi: 10.1182/blood-2008-12-193037. Epub 2009 Mar 23. Blood. 2009. PMID: 19307668 Free PMC article.

5

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.

Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. Cerchietti LC, et al. Nat Med. 2009 Dec;15(12):1369-76. doi: 10.1038/nm.2059. Epub 2009 Nov 22. Nat Med. 2009. PMID: 19966776 Free PMC article.

6

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A. Cerchietti LC, et al. Cancer Cell. 2010 Apr 13;17(4):400-11. doi: 10.1016/j.ccr.2009.12.050. Cancer Cell. 2010. PMID: 20385364 Free PMC article.

7

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma.

Shaknovich R, Geng H, Johnson NA, Tsikitas L, Cerchietti L, Greally JM, Gascoyne RD, Elemento O, Melnick A. Shaknovich R, et al. Blood. 2010 Nov 18;116(20):e81-9. doi: 10.1182/blood-2010-05-285320. Epub 2010 Jul 7. Blood. 2010. PMID: 20610814 Free PMC article.

8

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.

Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O. Velichutina I, et al. Among authors: melnick am. Blood. 2010 Dec 9;116(24):5247-55. doi: 10.1182/blood-2010-04-280149. Epub 2010 Aug 24. Blood. 2010. PMID: 20736451 Free PMC article.

9

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.

Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A. Cerchietti LC, et al. J Clin Invest. 2010 Dec 1;120(12):4569-82. doi: 10.1172/JCI42869. Epub 2010 Nov 1. J Clin Invest. 2010. PMID: 21041953 Free PMC article.

10

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.

Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, Ballon G, Yang SN, Weinhold N, Reimers M, Clozel T, Luttrop K, Ekstrom TJ, Frank J, Vasanthakumar A, Godley LA, Michor F, Elemento O, Melnick A. Shaknovich R, et al. Blood. 2011 Sep 29;118(13):3559-69. doi: 10.1182/blood-2011-06-357996. Epub 2011 Aug 9. Blood. 2011. PMID: 21828137 Free PMC article.

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