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Metabolomics enables precision medicine: "A White Paper, Community Perspective".
Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative. Beger RD, et al. Among authors: thiele i. Metabolomics. 2016;12(10):149. doi: 10.1007/s11306-016-1094-6. Epub 2016 Sep 2. Metabolomics. 2016. PMID: 27642271 Free PMC article.
Prediction of intracellular metabolic states from extracellular metabolomic data.
Aurich MK, Paglia G, Rolfsson Ó, Hrafnsdóttir S, Magnúsdóttir M, Stefaniak MM, Palsson BØ, Fleming RM, Thiele I. Aurich MK, et al. Among authors: thiele i. Metabolomics. 2015;11(3):603-619. doi: 10.1007/s11306-014-0721-3. Epub 2014 Aug 14. Metabolomics. 2015. PMID: 25972769 Free PMC article.
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.
Hertel J, Harms AC, Heinken A, Baldini F, Thinnes CC, Glaab E, Vasco DA, Pietzner M, Stewart ID, Wareham NJ, Langenberg C, Trenkwalder C, Krüger R, Hankemeier T, Fleming RMT, Mollenhauer B, Thiele I. Hertel J, et al. Among authors: thiele i. Cell Rep. 2019 Nov 12;29(7):1767-1777.e8. doi: 10.1016/j.celrep.2019.10.035. Cell Rep. 2019. PMID: 31722195 Free PMC article. Clinical Trial.
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.
Baloni P, Funk CC, Yan J, Yurkovich JT, Kueider-Paisley A, Nho K, Heinken A, Jia W, Mahmoudiandehkordi S, Louie G, Saykin AJ, Arnold M, Kastenmüller G, Griffiths WJ, Thiele I; Alzheimer’s Disease Metabolomics Consortium; Kaddurah-Daouk R, Price ND. Baloni P, et al. Among authors: thiele i. Cell Rep Med. 2020 Nov 17;1(8):100138. doi: 10.1016/j.xcrm.2020.100138. eCollection 2020 Nov 17. Cell Rep Med. 2020. PMID: 33294859 Free PMC article.
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer’s Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hernández AI, Kastenmüller G, Baillie R, Han X, Kaddurah-Daouk R. Baloni P, et al. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6. Commun Biol. 2022. PMID: 36209301 Free PMC article.
Circulating metabolites modulated by diet are associated with depression.
van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S, Heinken A, Luik AI, Ladwig KH, Kastenmüller G, Menni C, Hertel J, Ikram MA, de Mutsert R, Suhre K, Gieger C, Strauch K, Völzke H, Meitinger T, Mangino M, Flaquer A, Waldenberger M, Peters A, Thiele I, Kaddurah-Daouk R, Dunlop BW, Rosendaal FR, Wareham NJ, Spector TD, Kunze S, Grabe HJ, Mook-Kanamori DO, Langenberg C, van Duijn CM, Amin N. van der Spek A, et al. Among authors: thiele i. Mol Psychiatry. 2023 Sep;28(9):3874-3887. doi: 10.1038/s41380-023-02180-2. Epub 2023 Jul 26. Mol Psychiatry. 2023. PMID: 37495887 Free PMC article.
A community-driven global reconstruction of human metabolism.
Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bölling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novère N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BØ. Thiele I, et al. Nat Biotechnol. 2013 May;31(5):419-25. doi: 10.1038/nbt.2488. Epub 2013 Mar 3. Nat Biotechnol. 2013. PMID: 23455439 Free PMC article.
Systems biology of host-microbe metabolomics.
Heinken A, Thiele I. Heinken A, et al. Among authors: thiele i. Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug;7(4):195-219. doi: 10.1002/wsbm.1301. Epub 2015 Apr 30. Wiley Interdiscip Rev Syst Biol Med. 2015. PMID: 25929487 Free PMC article. Review.
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