Opferman J - Search Results

1

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.

Lee T, Bian Z, Zhao B, Hogdal LJ, Sensintaffar JL, Goodwin CM, Belmar J, Shaw S, Tarr JC, Veerasamy N, Matulis SM, Koss B, Fischer MA, Arnold AL, Camper DV, Browning CF, Rossanese OW, Budhraja A, Opferman J, Boise LH, Savona MR, Letai A, Olejniczak ET, Fesik SW. Lee T, et al. Among authors: opferman j. FEBS Lett. 2017 Jan;591(1):240-251. doi: 10.1002/1873-3468.12497. Epub 2016 Dec 19. FEBS Lett. 2017. PMID: 27878989 Free PMC article.

2

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Opferman JT, et al. Nature. 2003 Dec 11;426(6967):671-6. doi: 10.1038/nature02067. Nature. 2003. PMID: 14668867 Free article.

3

MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts.

Brunelle JK, Ryan J, Yecies D, Opferman JT, Letai A. Brunelle JK, et al. Among authors: opferman jt. J Cell Biol. 2009 Nov 2;187(3):429-42. doi: 10.1083/jcb.200904049. Epub 2009 Oct 26. J Cell Biol. 2009. PMID: 19948485 Free PMC article.

4

Ubiquitin-independent degradation of antiapoptotic MCL-1.

Stewart DP, Koss B, Bathina M, Perciavalle RM, Bisanz K, Opferman JT. Stewart DP, et al. Mol Cell Biol. 2010 Jun;30(12):3099-110. doi: 10.1128/MCB.01266-09. Epub 2010 Apr 12. Mol Cell Biol. 2010. PMID: 20385764 Free PMC article.

5

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

Xiang Z, Luo H, Payton JE, Cain J, Ley TJ, Opferman JT, Tomasson MH. Xiang Z, et al. Among authors: opferman jt. J Clin Invest. 2010 Jun;120(6):2109-18. doi: 10.1172/JCI39964. Epub 2010 May 17. J Clin Invest. 2010. PMID: 20484815 Free PMC article.

6

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Perciavalle RM, et al. Among authors: opferman jt. Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488. Nat Cell Biol. 2012. PMID: 22544066 Free PMC article.

7

A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.

Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD. Cohen NA, et al. Chem Biol. 2012 Sep 21;19(9):1175-86. doi: 10.1016/j.chembiol.2012.07.018. Chem Biol. 2012. PMID: 22999885 Free PMC article.

8

Delving deeper: MCL-1's contributions to normal and cancer biology.

Perciavalle RM, Opferman JT. Perciavalle RM, et al. Trends Cell Biol. 2013 Jan;23(1):22-9. doi: 10.1016/j.tcb.2012.08.011. Epub 2012 Sep 28. Trends Cell Biol. 2013. PMID: 23026029 Free PMC article. Review.

9

Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.

Tripathi P, Koss B, Opferman JT, Hildeman DA. Tripathi P, et al. Among authors: opferman jt. Cell Death Differ. 2013 Aug;20(8):998-1007. doi: 10.1038/cdd.2013.25. Epub 2013 Apr 5. Cell Death Differ. 2013. PMID: 23558951 Free PMC article.

10

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.

Wang X, Bathina M, Lynch J, Koss B, Calabrese C, Frase S, Schuetz JD, Rehg JE, Opferman JT. Wang X, et al. Among authors: opferman jt. Genes Dev. 2013 Jun 15;27(12):1351-64. doi: 10.1101/gad.215855.113. Genes Dev. 2013. PMID: 23788622 Free PMC article.

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