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The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H. Nøhr AC, et al. Among authors: pedersen ds. Neurochem Int. 2017 Jan;102:105-113. doi: 10.1016/j.neuint.2016.11.012. Epub 2016 Dec 1. Neurochem Int. 2017. PMID: 27916541 Free PMC article.
Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.
Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne H. Pedersen MF, et al. Among authors: pedersen ds. Neuropharmacology. 2020 Apr;166:107718. doi: 10.1016/j.neuropharm.2019.107718. Epub 2019 Jul 24. Neuropharmacology. 2020. PMID: 31351108 Free article.
1,2,3-triazolyl amino acids as AMPA receptor ligands.
Stanley NJ, Pedersen DS, Nielsen B, Kvist T, Mathiesen JM, Bräuner-Osborne H, Taylor DK, Abell AD. Stanley NJ, et al. Among authors: pedersen ds. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7512-5. doi: 10.1016/j.bmcl.2010.09.139. Epub 2010 Oct 14. Bioorg Med Chem Lett. 2010. PMID: 21036612
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.
Stanley NJ, Hutchinson MR, Kvist T, Nielsen B, Mathiesen JM, Bräuner-Osborne H, Avery TD, Tiekink ER, Pedersen DS, Irvine RJ, Abell AD, Taylor DK. Stanley NJ, et al. Among authors: pedersen ds. Bioorg Med Chem. 2010 Aug 15;18(16):6089-98. doi: 10.1016/j.bmc.2010.06.051. Epub 2010 Jun 25. Bioorg Med Chem. 2010. PMID: 20638290
Aspartame as a co-former in co-amorphous systems.
Wu W, Löbmann K, Schnitzkewitz J, Knuhtsen A, Pedersen DS, Grohganz H, Rades T. Wu W, et al. Among authors: pedersen ds. Int J Pharm. 2018 Oct 5;549(1-2):380-387. doi: 10.1016/j.ijpharm.2018.07.063. Epub 2018 Jul 31. Int J Pharm. 2018. PMID: 30075253
Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor.
Boyhus LE, Danielsen M, Bengtson NS, Ben Achim Kunze M, Kubiak X, Sminia TJ, Løper JH, Tran PT, Lindorff-Larsen K, Rasmussen SGF, Mathiesen JM, Pedersen DS. Boyhus LE, et al. Among authors: pedersen ds. RSC Adv. 2018 Jan 9;8(4):2219-2228. doi: 10.1039/c7ra11713b. eCollection 2018 Jan 5. RSC Adv. 2018. PMID: 35542596 Free PMC article.
Dipeptides as co-formers in co-amorphous systems.
Wu W, Löbmann K, Schnitzkewitz J, Knuhtsen A, Pedersen DS, Rades T, Grohganz H. Wu W, et al. Among authors: pedersen ds. Eur J Pharm Biopharm. 2019 Jan;134:68-76. doi: 10.1016/j.ejpb.2018.11.016. Epub 2018 Nov 20. Eur J Pharm Biopharm. 2019. PMID: 30468836
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