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Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Lamoral-Theys D, Andolfi A, Van Goietsenoven G, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, Mathieu V, Kornienko A, Kiss R, Evidente A. Lamoral-Theys D, et al. Among authors: kornienko a. J Med Chem. 2009 Oct 22;52(20):6244-56. doi: 10.1021/jm901031h. J Med Chem. 2009. PMID: 19788245 Free PMC article.
Lycorine and its derivatives for anticancer drug design.
Lamoral-Theys D, Decaestecker C, Mathieu V, Dubois J, Kornienko A, Kiss R, Evidente A, Pottier L. Lamoral-Theys D, et al. Among authors: kornienko a. Mini Rev Med Chem. 2010 Jan;10(1):41-50. doi: 10.2174/138955710791112604. Mini Rev Med Chem. 2010. PMID: 20105122 Review.
Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.
Lamoral-Theys D, Pottier L, Kerff F, Dufrasne F, Proutière F, Wauthoz N, Neven P, Ingrassia L, Antwerpen PV, Lefranc F, Gelbcke M, Pirotte B, Kraus JL, Nève J, Kornienko A, Kiss R, Dubois J. Lamoral-Theys D, et al. Among authors: kornienko a. Bioorg Med Chem. 2010 Jun 1;18(11):3823-33. doi: 10.1016/j.bmc.2010.04.047. Epub 2010 Apr 21. Bioorg Med Chem. 2010. PMID: 20466556 Free PMC article.
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.
Van Goietsenoven G, Hutton J, Becker JP, Lallemand B, Robert F, Lefranc F, Pirker C, Vandenbussche G, Van Antwerpen P, Evidente A, Berger W, Prévost M, Pelletier J, Kiss R, Kinzy TG, Kornienko A, Mathieu V. Van Goietsenoven G, et al. Among authors: kornienko a. FASEB J. 2010 Nov;24(11):4575-84. doi: 10.1096/fj.10-162263. Epub 2010 Jul 19. FASEB J. 2010. PMID: 20643906 Free PMC article.
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.
Evdokimov NM, Van Slambrouck S, Heffeter P, Tu L, Le Calvé B, Lamoral-Theys D, Hooten CJ, Uglinskii PY, Rogelj S, Kiss R, Steelant WF, Berger W, Yang JJ, Bologa CG, Kornienko A, Magedov IV. Evdokimov NM, et al. Among authors: kornienko a. J Med Chem. 2011 Apr 14;54(7):2012-21. doi: 10.1021/jm1009428. Epub 2011 Mar 9. J Med Chem. 2011. PMID: 21388138 Free PMC article.
In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.
Evdokimov NM, Lamoral-Theys D, Mathieu V, Andolfi A, Frolova LV, Pelly SC, van Otterlo WA, Magedov IV, Kiss R, Evidente A, Kornienko A. Evdokimov NM, et al. Among authors: kornienko a. Bioorg Med Chem. 2011 Dec 1;19(23):7252-61. doi: 10.1016/j.bmc.2011.09.051. Epub 2011 Oct 2. Bioorg Med Chem. 2011. PMID: 22019045 Free PMC article.
Phenazines and cancer.
Cimmino A, Evidente A, Mathieu V, Andolfi A, Lefranc F, Kornienko A, Kiss R. Cimmino A, et al. Among authors: kornienko a. Nat Prod Rep. 2012 Apr;29(4):487-501. doi: 10.1039/c2np00079b. Epub 2012 Feb 15. Nat Prod Rep. 2012. PMID: 22337153 Review.
212 results