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Fatty Acid Cysteamine Conjugates as Novel and Potent Autophagy Activators That Enhance the Correction of Misfolded F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Vu CB, Bridges RJ, Pena-Rasgado C, Lacerda AE, Bordwell C, Sewell A, Nichols AJ, Chandran S, Lonkar P, Picarella D, Ting A, Wensley A, Yeager M, Liu F. Vu CB, et al. J Med Chem. 2017 Jan 12;60(1):458-473. doi: 10.1021/acs.jmedchem.6b01539. Epub 2016 Dec 23. J Med Chem. 2017. PMID: 27976892
Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid.
Vu CB, Bemis JE, Benson E, Bista P, Carney D, Fahrner R, Lee D, Liu F, Lonkar P, Milne JC, Nichols AJ, Picarella D, Shoelson A, Smith J, Ting A, Wensley A, Yeager M, Zimmer M, Jirousek MR. Vu CB, et al. J Med Chem. 2016 Feb 11;59(3):1217-31. doi: 10.1021/acs.jmedchem.5b01961. Epub 2016 Feb 1. J Med Chem. 2016. PMID: 26784936
CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.
Zimmer M, Bista P, Benson EL, Lee DY, Liu F, Picarella D, Vega RB, Vu CB, Yeager M, Ding M, Liang G, Horton JD, Kleemann R, Kooistra T, Morrison MC, Wielinga PY, Milne JC, Jirousek MR, Nichols AJ. Zimmer M, et al. Among authors: vu cb. Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun. Hepatol Commun. 2017. PMID: 29404461 Free PMC article.
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. Vu CB, et al. J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954. J Med Chem. 2009. PMID: 19199480
Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70.
Vu CB, Corpuz EG, Pradeepan SG, Violette S, Bartlett C, Sawyer TK. Vu CB, et al. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3009-14. doi: 10.1016/s0960-894x(99)00524-7. Bioorg Med Chem Lett. 1999. PMID: 10571165
25 results