Homma S - Search Results

1

Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.

Wu W, Chordia MD, Hart BP, Kumarasinghe ES, Ji MK, Bhargava A, Lawlor MW, Shin JY, Sera F, Homma S, Muchir A, Khire UR, Worman HJ. Wu W, et al. Among authors: homma s. Bioorg Med Chem. 2017 Feb 1;25(3):1004-1013. doi: 10.1016/j.bmc.2016.12.014. Epub 2016 Dec 9. Bioorg Med Chem. 2017. PMID: 28011205 Free PMC article.

2

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.

Muchir A, Reilly SA, Wu W, Iwata S, Homma S, Bonne G, Worman HJ. Muchir A, et al. Among authors: homma s. Cardiovasc Res. 2012 Feb 1;93(2):311-9. doi: 10.1093/cvr/cvr301. Epub 2011 Nov 8. Cardiovasc Res. 2012. PMID: 22068161

3

Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation.

Muchir A, Wu W, Choi JC, Iwata S, Morrow J, Homma S, Worman HJ. Muchir A, et al. Among authors: homma s. Hum Mol Genet. 2012 Oct 1;21(19):4325-33. doi: 10.1093/hmg/dds265. Epub 2012 Jul 5. Hum Mol Genet. 2012. PMID: 22773734 Free PMC article.

4

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.

Choi JC, Muchir A, Wu W, Iwata S, Homma S, Morrow JP, Worman HJ. Choi JC, et al. Among authors: homma s. Sci Transl Med. 2012 Jul 25;4(144):144ra102. doi: 10.1126/scitranslmed.3003875. Sci Transl Med. 2012. PMID: 22837537 Free PMC article.

5

Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.

Choi JC, Wu W, Muchir A, Iwata S, Homma S, Worman HJ. Choi JC, et al. Among authors: homma s. J Biol Chem. 2012 Nov 23;287(48):40513-24. doi: 10.1074/jbc.M112.404541. Epub 2012 Oct 9. J Biol Chem. 2012. PMID: 23048029 Free PMC article.

6

Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation.

Muchir A, Wu W, Sera F, Homma S, Worman HJ. Muchir A, et al. Among authors: homma s. Biochem Biophys Res Commun. 2014 Oct 3;452(4):958-61. doi: 10.1016/j.bbrc.2014.09.020. Epub 2014 Sep 11. Biochem Biophys Res Commun. 2014. PMID: 25218145 Free PMC article.

7

Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.

Choi JC, Wu W, Phillips E, Plevin R, Sera F, Homma S, Worman HJ. Choi JC, et al. Among authors: homma s. Hum Mol Genet. 2018 Jul 1;27(13):2290-2305. doi: 10.1093/hmg/ddy134. Hum Mol Genet. 2018. PMID: 29668927 Free PMC article.

8

Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.

Wu W, Iwata S, Homma S, Worman HJ, Muchir A. Wu W, et al. Among authors: homma s. Hum Mol Genet. 2014 Jan 1;23(1):1-11. doi: 10.1093/hmg/ddt387. Epub 2013 Aug 9. Hum Mol Genet. 2014. PMID: 23933734 Free PMC article.

9

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.

Chatzifrangkeskou M, Le Dour C, Wu W, Morrow JP, Joseph LC, Beuvin M, Sera F, Homma S, Vignier N, Mougenot N, Bonne G, Lipson KE, Worman HJ, Muchir A. Chatzifrangkeskou M, et al. Among authors: homma s. Hum Mol Genet. 2016 Jun 1;25(11):2220-2233. doi: 10.1093/hmg/ddw090. Epub 2016 Apr 30. Hum Mol Genet. 2016. PMID: 27131347 Free PMC article.

10

Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene.

Le Dour C, Macquart C, Sera F, Homma S, Bonne G, Morrow JP, Worman HJ, Muchir A. Le Dour C, et al. Among authors: homma s. Hum Mol Genet. 2017 Jan 15;26(2):333-343. doi: 10.1093/hmg/ddw389. Hum Mol Genet. 2017. PMID: 28069793 Free PMC article.

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