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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
Vulpetti A, Randl S, Rüdisser S, Ostermann N, Erbel P, Mac Sweeney A, Zoller T, Salem B, Gerhartz B, Cumin F, Hommel U, Dalvit C, Lorthiois E, Maibaum J. Vulpetti A, et al. Among authors: rudisser s. J Med Chem. 2017 Mar 9;60(5):1946-1958. doi: 10.1021/acs.jmedchem.6b01684. Epub 2017 Feb 20. J Med Chem. 2017. PMID: 28157311
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K. Maibaum J, et al. Among authors: rudisser s. Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24. Nat Chem Biol. 2016. PMID: 27775713
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Lorthiois E, Anderson K, Vulpetti A, Rogel O, Cumin F, Ostermann N, Steinbacher S, Mac Sweeney A, Delgado O, Liao SM, Randl S, Rüdisser S, Dussauge S, Fettis K, Kieffer L, de Erkenez A, Yang L, Hartwieg C, Argikar UA, La Bonte LR, Newton R, Kansara V, Flohr S, Hommel U, Jaffee B, Maibaum J. Lorthiois E, et al. Among authors: rudisser s. J Med Chem. 2017 Jul 13;60(13):5717-5735. doi: 10.1021/acs.jmedchem.7b00425. Epub 2017 Jun 30. J Med Chem. 2017. PMID: 28621538
NMR and in silico screening.
Rüdisser S, Jahnke W. Rüdisser S, et al. Comb Chem High Throughput Screen. 2002 Dec;5(8):591-603. doi: 10.2174/1386207023329987. Comb Chem High Throughput Screen. 2002. PMID: 12470256 Review.
Spin label enhanced NMR screening.
Jahnke W, Rüdisser S, Zurini M. Jahnke W, et al. Among authors: rudisser s. J Am Chem Soc. 2001 Apr 4;123(13):3149-50. doi: 10.1021/ja005836g. J Am Chem Soc. 2001. PMID: 11457032 No abstract available.
20 results