Moutinho M - Search Results

1

The mevalonate pathway in neurons: It's not just about cholesterol.

Moutinho M, Nunes MJ, Rodrigues E. Moutinho M, et al. Exp Cell Res. 2017 Nov 1;360(1):55-60. doi: 10.1016/j.yexcr.2017.02.034. Epub 2017 Feb 21. Exp Cell Res. 2017. PMID: 28232115 Review.

2

Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.

Nunes MJ, Moutinho M, Milagre I, Gama MJ, Rodrigues E. Nunes MJ, et al. Among authors: moutinho m. J Lipid Res. 2012 Sep;53(9):1910-9. doi: 10.1194/jlr.M027680. Epub 2012 Jun 12. J Lipid Res. 2012. PMID: 22693257 Free PMC article.

3

Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.

Moutinho M, Nunes MJ, Gomes AQ, Gama MJ, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Rodrigues E. Moutinho M, et al. Mol Neurobiol. 2015;51(3):1489-503. doi: 10.1007/s12035-014-8828-0. Epub 2014 Aug 2. Mol Neurobiol. 2015. PMID: 25084760

4

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Ruas JL, Rodrigues E. Moutinho M, et al. Sci Rep. 2016 Aug 5;6:30928. doi: 10.1038/srep30928. Sci Rep. 2016. PMID: 27491694 Free PMC article.

5

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond.

Moutinho M, Nunes MJ, Rodrigues E. Moutinho M, et al. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1911-1920. doi: 10.1016/j.bbalip.2016.09.011. Epub 2016 Sep 20. Biochim Biophys Acta. 2016. PMID: 27663182 Review.

6

Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination.

Milagre I, Nunes MJ, Moutinho M, Rivera I, Fuso A, Scarpa S, Gama MJ, Rodrigues E. Milagre I, et al. Among authors: moutinho m. J Alzheimers Dis. 2010;22(4):1209-21. doi: 10.3233/JAD-2010-100651. J Alzheimers Dis. 2010. PMID: 20930312

7

Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter.

Milagre I, Nunes MJ, Castro-Caldas M, Moutinho M, Gama MJ, Rodrigues E. Milagre I, et al. Among authors: moutinho m. J Neurochem. 2012 Jan;120(2):220-9. doi: 10.1111/j.1471-4159.2011.07577.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22060190 Free article.

8

Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.

Milagre I, Olin M, Nunes MJ, Moutinho M, Lövgren-Sandblom A, Gama MJ, Björkhem I, Rodrigues E. Milagre I, et al. Among authors: moutinho m. Neurochem Int. 2012 Jan;60(2):192-8. doi: 10.1016/j.neuint.2011.12.003. Epub 2011 Dec 13. Neurochem Int. 2012. PMID: 22185844

9

Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux.

Nunes MJ, Moutinho M, Gama MJ, Rodrigues CM, Rodrigues E. Nunes MJ, et al. Among authors: moutinho m. PLoS One. 2013;8(1):e53394. doi: 10.1371/journal.pone.0053394. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326422 Free PMC article.

10

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.

Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Jadhav VS, et al. Among authors: moutinho m. Mol Neurodegener. 2020 Oct 28;15(1):62. doi: 10.1186/s13024-020-00409-0. Mol Neurodegener. 2020. PMID: 33115519 Free PMC article.

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