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Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.
Mukherjee S, Russell JC, Carr DT, Burgess JD, Allen M, Serie DJ, Boehme KL, Kauwe JSK, Naj AC, Fardo DW, Dickson DW, Montine TJ, Ertekin-Taner N, Kaeberlein MR, Crane PK. Mukherjee S, et al. Among authors: kaeberlein mr. Alzheimers Dement. 2017 Oct;13(10):1133-1142. doi: 10.1016/j.jalz.2017.01.016. Epub 2017 Feb 24. Alzheimers Dement. 2017. PMID: 28242297 Free PMC article.
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, Peng ZJ, Rai D, Ros V, Singh M, Wende HV, Kennedy BK, Kaeberlein M. Delaney JR, et al. Aging Cell. 2013 Feb;12(1):156-66. doi: 10.1111/acel.12032. Epub 2012 Dec 25. Aging Cell. 2013. PMID: 23167605 Free PMC article.
Buffering the pH of the culture medium does not extend yeast replicative lifespan.
Wasko BM, Carr DT, Tung H, Doan H, Schurman N, Neault JR, Feng J, Lee J, Zipkin B, Mouser J, Oudanonh E, Nguyen T, Stetina T, Shemorry A, Lemma M, Kaeberlein M. Wasko BM, et al. F1000Res. 2013 Oct 15;2:216. doi: 10.12688/f1000research.2-216.v1. eCollection 2013. F1000Res. 2013. PMID: 24555104 Free PMC article.
H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. Sen P, et al. Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115. Genes Dev. 2015. PMID: 26159996 Free PMC article.
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.
Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M. Bennett CF, et al. PLoS Genet. 2017 Mar 29;13(3):e1006695. doi: 10.1371/journal.pgen.1006695. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28355222 Free PMC article.
243 results