Parks JM - Search Results

1

Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives.

Goins CM, Dajnowicz S, Thanna S, Sucheck SJ, Parks JM, Ronning DR. Goins CM, et al. Among authors: parks jm. ACS Infect Dis. 2017 May 12;3(5):378-387. doi: 10.1021/acsinfecdis.7b00003. Epub 2017 Mar 21. ACS Infect Dis. 2017. PMID: 28285521 Free PMC article.

2

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump.

Abdali N, Parks JM, Haynes KM, Chaney JL, Green AT, Wolloscheck D, Walker JK, Rybenkov VV, Baudry J, Smith JC, Zgurskaya HI. Abdali N, et al. Among authors: parks jm. ACS Infect Dis. 2017 Jan 13;3(1):89-98. doi: 10.1021/acsinfecdis.6b00167. Epub 2016 Nov 2. ACS Infect Dis. 2017. PMID: 27768847 Free PMC article.

3

Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5'-phosphate in aspartate aminotransferase.

Dajnowicz S, Parks JM, Hu X, Gesler K, Kovalevsky AY, Mueser TC. Dajnowicz S, et al. Among authors: parks jm. J Biol Chem. 2017 Apr 7;292(14):5970-5980. doi: 10.1074/jbc.M116.774588. Epub 2017 Feb 23. J Biol Chem. 2017. PMID: 28232482 Free PMC article.

4

Direct visualization of critical hydrogen atoms in a pyridoxal 5'-phosphate enzyme.

Dajnowicz S, Johnston RC, Parks JM, Blakeley MP, Keen DA, Weiss KL, Gerlits O, Kovalevsky A, Mueser TC. Dajnowicz S, et al. Among authors: parks jm. Nat Commun. 2017 Oct 16;8(1):955. doi: 10.1038/s41467-017-01060-y. Nat Commun. 2017. PMID: 29038582 Free PMC article.

5

Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis.

Goins CM, Dajnowicz S, Smith MD, Parks JM, Ronning DR. Goins CM, et al. Among authors: parks jm. J Biol Chem. 2018 Mar 9;293(10):3651-3662. doi: 10.1074/jbc.RA117.001681. Epub 2018 Jan 19. J Biol Chem. 2018. PMID: 29352107 Free PMC article.

6

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa.

Cooper CJ, Krishnamoorthy G, Wolloscheck D, Walker JK, Rybenkov VV, Parks JM, Zgurskaya HI. Cooper CJ, et al. Among authors: parks jm. ACS Infect Dis. 2018 Aug 10;4(8):1223-1234. doi: 10.1021/acsinfecdis.8b00036. Epub 2018 May 25. ACS Infect Dis. 2018. PMID: 29756762 Free PMC article.

7

Conformational Dynamics of AcrA Govern Multidrug Efflux Pump Assembly.

Hazel AJ, Abdali N, Leus IV, Parks JM, Smith JC, Zgurskaya HI, Gumbart JC. Hazel AJ, et al. Among authors: parks jm. ACS Infect Dis. 2019 Nov 8;5(11):1926-1935. doi: 10.1021/acsinfecdis.9b00273. Epub 2019 Sep 26. ACS Infect Dis. 2019. PMID: 31517484 Free PMC article.

8

Mechanistic Duality of Bacterial Efflux Substrates and Inhibitors: Example of Simple Substituted Cinnamoyl and Naphthyl Amides.

D'Cunha N, Moniruzzaman M, Haynes K, Malloci G, Cooper CJ, Margiotta E, Vargiu AV, Uddin MR, Leus IV, Cao F, Parks JM, Rybenkov VV, Ruggerone P, Zgurskaya HI, Walker JK. D'Cunha N, et al. Among authors: parks jm. ACS Infect Dis. 2021 Sep 10;7(9):2650-2665. doi: 10.1021/acsinfecdis.1c00100. Epub 2021 Aug 11. ACS Infect Dis. 2021. PMID: 34379382 Free PMC article.

9

Analysis of Orthogonal Efflux and Permeation Properties of Compounds Leads to the Discovery of New Efflux Pump Inhibitors.

Moniruzzaman M, Cooper CJ, Uddin MR, Walker JK, Parks JM, Zgurskaya HI. Moniruzzaman M, et al. Among authors: parks jm. ACS Infect Dis. 2022 Oct 14;8(10):2149-2160. doi: 10.1021/acsinfecdis.2c00263. Epub 2022 Sep 7. ACS Infect Dis. 2022. PMID: 36070489 Free PMC article.

10

An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction.

Drago VN, Dajnowicz S, Parks JM, Blakeley MP, Keen DA, Coquelle N, Weiss KL, Gerlits O, Kovalevsky A, Mueser TC. Drago VN, et al. Among authors: parks jm. Chem Sci. 2022 Aug 17;13(34):10057-10065. doi: 10.1039/d2sc02285k. eCollection 2022 Aug 31. Chem Sci. 2022. PMID: 36128223 Free PMC article.

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