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Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
Nikiforov PO, Blaszczyk M, Surade S, Boshoff HI, Sajid A, Delorme V, Deboosere N, Brodin P, Baulard AR, Barry CE 3rd, Blundell TL, Abell C. Nikiforov PO, et al. Among authors: blaszczyk m. ACS Chem Biol. 2017 May 19;12(5):1390-1396. doi: 10.1021/acschembio.7b00091. Epub 2017 Apr 5. ACS Chem Biol. 2017. PMID: 28314097 Free PMC article.
Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes.
Sridharan S, Howard N, Kerbarh O, Błaszczyk M, Abell C, Blundell TL. Sridharan S, et al. Among authors: blaszczyk m. J Mol Biol. 2010 Mar 19;397(1):290-300. doi: 10.1016/j.jmb.2010.01.019. Epub 2010 Jan 15. J Mol Biol. 2010. PMID: 20079748
Structural insights into the EthR-DNA interaction using native mass spectrometry.
Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Shiu-Hin Chan D, et al. Among authors: blaszczyk m. Chem Commun (Camb). 2017 Mar 23;53(25):3527-3530. doi: 10.1039/c7cc00804j. Chem Commun (Camb). 2017. PMID: 28287239 Free PMC article.
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Mendes V, Green SR, Evans JC, Hess J, Blaszczyk M, Spry C, Bryant O, Cory-Wright J, Chan DS, Torres PHM, Wang Z, Nahiyaan N, O'Neill S, Damerow S, Post J, Bayliss T, Lynch SL, Coyne AG, Ray PC, Abell C, Rhee KY, Boshoff HIM, Barry CE 3rd, Mizrahi V, Wyatt PG, Blundell TL. Mendes V, et al. Among authors: blaszczyk m. Nat Commun. 2021 Jan 8;12(1):143. doi: 10.1038/s41467-020-20224-x. Nat Commun. 2021. PMID: 33420031 Free PMC article.
333 results