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Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Sakurada I, Endo T, Hikita K, Hirabayashi T, Hosaka Y, Kato Y, Maeda Y, Matsumoto S, Mizuno T, Nagasue H, Nishimura T, Shimada S, Shinozaki M, Taguchi K, Takeuchi K, Yokoyama T, Hruza A, Reichert P, Zhang T, Wood HB, Nakao K, Furusako S. Sakurada I, et al. Among authors: kato y. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2622-2628. doi: 10.1016/j.bmcl.2017.03.002. Epub 2017 Mar 6. Bioorg Med Chem Lett. 2017. PMID: 28408226
Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [(E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidin-1-yl)pyrimidin-4-yl)morpholine] in rats: potential for the treatment of schizophrenia.
Arakawa K, Maehara S, Yuge N, Ishikawa M, Miyazaki Y, Naba H, Kato Y, Nakao K. Arakawa K, et al. Among authors: kato y. Pharmacol Res Perspect. 2016 Jun 10;4(4):e00241. doi: 10.1002/prp2.241. eCollection 2016 Aug. Pharmacol Res Perspect. 2016. PMID: 28116094 Free PMC article.
8,494 results