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Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay.
Iwatani-Yoshihara M, Ito M, Ishibashi Y, Oki H, Tanaka T, Morishita D, Ito T, Kimura H, Imaeda Y, Aparicio S, Nakanishi A, Kawamoto T. Iwatani-Yoshihara M, et al. Among authors: morishita d. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768. doi: 10.1021/acschembio.7b00041. Epub 2017 May 10. ACS Chem Biol. 2017. PMID: 28440616
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S. Funnell T, et al. Among authors: morishita d, morishita n. Nat Commun. 2017 Feb 23;8(1):7. doi: 10.1038/s41467-016-0008-7. Nat Commun. 2017. PMID: 28232751 Free PMC article.
High-Throughput Screening to Identify Inhibitors of DEAD Box Helicase DDX41.
Yoneyama-Hirozane M, Kondo M, Matsumoto SI, Morikawa-Oki A, Morishita D, Nakanishi A, Kawamoto T, Nakayama M. Yoneyama-Hirozane M, et al. Among authors: morishita d. SLAS Discov. 2017 Oct;22(9):1084-1092. doi: 10.1177/2472555217705952. Epub 2017 Apr 20. SLAS Discov. 2017. PMID: 28426938 Free article.
Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
Iwatani-Yoshihara M, Ito M, Klein MG, Yamamoto T, Yonemori K, Tanaka T, Miwa M, Morishita D, Endo S, Tjhen R, Qin L, Nakanishi A, Maezaki H, Kawamoto T. Iwatani-Yoshihara M, et al. Among authors: morishita d. J Med Chem. 2017 Jul 13;60(13):5759-5771. doi: 10.1021/acs.jmedchem.7b00461. Epub 2017 Jun 20. J Med Chem. 2017. PMID: 28586220
Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors.
Mizojiri R, Nakata D, Satoh Y, Morishita D, Shibata S, Iwatani-Yoshihara M, Kosugi Y, Kosaka M, Takeda J, Sasaki S, Takami K, Fukuda K, Kamaura M, Sasaki S, Arai R, Cary DR, Imaeda Y. Mizojiri R, et al. Among authors: morishita d. ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082. doi: 10.1021/acsmedchemlett.7b00283. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057054 Free PMC article.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
Tanaka Y, Kurasawa O, Yokota A, Klein MG, Saito B, Matsumoto S, Okaniwa M, Ambrus-Aikelin G, Uchiyama N, Morishita D, Kimura H, Imamura S. Tanaka Y, et al. Among authors: morishita d. ACS Med Chem Lett. 2020 Jul 30;11(8):1645-1652. doi: 10.1021/acsmedchemlett.0c00331. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 34345355 Free PMC article.
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
Tanaka Y, Kurasawa O, Yokota A, Klein MG, Ono K, Saito B, Matsumoto S, Okaniwa M, Ambrus-Aikelin G, Morishita D, Kitazawa S, Uchiyama N, Ogawa K, Kimura H, Imamura S. Tanaka Y, et al. Among authors: morishita d. J Med Chem. 2020 Mar 26;63(6):3215-3226. doi: 10.1021/acs.jmedchem.9b01979. Epub 2020 Mar 16. J Med Chem. 2020. PMID: 32142284
57 results