Scarfe G - Search Results

1

In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450.

McCormick A, Swaisland H, Reddy VP, Learoyd M, Scarfe G. McCormick A, et al. Among authors: scarfe g. Xenobiotica. 2018 Jun;48(6):555-564. doi: 10.1080/00498254.2017.1346332. Epub 2017 Jul 25. Xenobiotica. 2018. PMID: 28657402

2

Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations.

Pilla Reddy V, Bui K, Scarfe G, Zhou D, Learoyd M. Pilla Reddy V, et al. Among authors: scarfe g. Clin Pharmacol Ther. 2019 Jan;105(1):229-241. doi: 10.1002/cpt.1103. Epub 2018 Aug 9. Clin Pharmacol Ther. 2019. PMID: 29717476 Free PMC article.

3

CYP-Mediated Sulfoximine Deimination of AZD6738.

Jones BC, Markandu R, Gu C, Scarfe G. Jones BC, et al. Among authors: scarfe g. Drug Metab Dispos. 2017 Nov;45(11):1133-1138. doi: 10.1124/dmd.117.077776. Epub 2017 Aug 23. Drug Metab Dispos. 2017. PMID: 28835442

4

Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.

Ren S, Vishwanathan K, Cantarini M, Frewer P, Hara I, Scarfe G, Burke W, Schalkwijk S, Li Y, Han D, Goldwater R. Ren S, et al. Among authors: scarfe g. Br J Clin Pharmacol. 2022 Feb;88(2):655-668. doi: 10.1111/bcp.14994. Epub 2021 Aug 21. Br J Clin Pharmacol. 2022. PMID: 34322894 Free PMC article.

5

19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling.

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JK. Scarfe GB, et al. Xenobiotica. 1998 Apr;28(4):373-88. doi: 10.1080/004982598239489. Xenobiotica. 1998. PMID: 9604301

6

Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS.

Scarfe GB, Lindon JC, Nicholson JK, Martin P, Wright B, Taylor S, Lenz E, Wilson ID. Scarfe GB, et al. Xenobiotica. 2000 Jul;30(7):717-29. doi: 10.1080/00498250050078020. Xenobiotica. 2000. PMID: 10963062

7

The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.

Pichard-Garcia L, Weaver RJ, Eckett N, Scarfe G, Fabre JM, Lucas C, Maurel P. Pichard-Garcia L, et al. Among authors: scarfe g. Drug Metab Dispos. 2004 Jan;32(1):80-8. doi: 10.1124/dmd.32.1.80. Drug Metab Dispos. 2004. PMID: 14709624

8

Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.

Young GC, Spracklin DK, James AD, Hvenegaard MG, Scarfe G, Wagner DS, Georgi K, Schieferstein H, Bjornsdottir I, van Groen B, Romeo AA, Cassidy KC, Da-Violante G, Bister B, Blech S, Lyer R, Schulz SI, Cuyckens F, Moliner P. Young GC, et al. Among authors: scarfe g. Clin Pharmacol Ther. 2023 Apr;113(4):775-781. doi: 10.1002/cpt.2691. Epub 2022 Sep 2. Clin Pharmacol Ther. 2023. PMID: 35733280

9

Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS.

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JK. Scarfe GB, et al. Xenobiotica. 1999 Jan;29(1):77-91. doi: 10.1080/004982599238821. Xenobiotica. 1999. PMID: 10078841

10

Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.

Degorce SL, Aagaard A, Anjum R, Cumming IA, Diène CR, Fallan C, Johnson T, Leuchowius KJ, Orton AL, Pearson S, Robb GR, Rosen A, Scarfe GB, Scott JS, Smith JM, Steward OR, Terstiege I, Tucker MJ, Turner P, Wilkinson SD, Wrigley GL, Xue Y. Degorce SL, et al. Among authors: scarfe gb. Bioorg Med Chem. 2020 Dec 1;28(23):115815. doi: 10.1016/j.bmc.2020.115815. Epub 2020 Oct 15. Bioorg Med Chem. 2020. PMID: 33091850

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