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De novo active sites for resurrected Precambrian enzymes.
Risso VA, Martinez-Rodriguez S, Candel AM, Krüger DM, Pantoja-Uceda D, Ortega-Muñoz M, Santoyo-Gonzalez F, Gaucher EA, Kamerlin SCL, Bruix M, Gavira JA, Sanchez-Ruiz JM. Risso VA, et al. Among authors: candel am. Nat Commun. 2017 Jul 18;8:16113. doi: 10.1038/ncomms16113. Nat Commun. 2017. PMID: 28719578 Free PMC article.
Fast folding and slow unfolding of a resurrected Precambrian protein.
Candel AM, Romero-Romero ML, Gamiz-Arco G, Ibarra-Molero B, Sanchez-Ruiz JM. Candel AM, et al. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4122-E4123. doi: 10.1073/pnas.1703227114. Epub 2017 May 16. Proc Natl Acad Sci U S A. 2017. PMID: 28512228 Free PMC article. No abstract available.
A binding event converted into a folding event.
Martín-Sierra FM, Candel AM, Casares S, Filimonov VV, Martínez JC, Conejero-Lara F. Martín-Sierra FM, et al. Among authors: candel am. FEBS Lett. 2003 Oct 23;553(3):328-32. doi: 10.1016/s0014-5793(03)01038-x. FEBS Lett. 2003. PMID: 14572645 Free article.
Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals.
Castillo F, Corbi-Verge C, Murciano-Calles J, Candel AM, Han Z, Iglesias-Bexiga M, Ruiz-Sanz J, Kim PM, Harty RN, Martinez JC, Luque I. Castillo F, et al. Among authors: candel am. Int J Biol Macromol. 2022 May 15;207:308-323. doi: 10.1016/j.ijbiomac.2022.03.010. Epub 2022 Mar 5. Int J Biol Macromol. 2022. PMID: 35257734 Free article.
14 results