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De novo active sites for resurrected Precambrian enzymes.
Risso VA, Martinez-Rodriguez S, Candel AM, Krüger DM, Pantoja-Uceda D, Ortega-Muñoz M, Santoyo-Gonzalez F, Gaucher EA, Kamerlin SCL, Bruix M, Gavira JA, Sanchez-Ruiz JM. Risso VA, et al. Among authors: kamerlin scl. Nat Commun. 2017 Jul 18;8:16113. doi: 10.1038/ncomms16113. Nat Commun. 2017. PMID: 28719578 Free PMC article.
Cooperativity and flexibility in enzyme evolution.
Pabis A, Risso VA, Sanchez-Ruiz JM, Kamerlin SC. Pabis A, et al. Curr Opin Struct Biol. 2018 Feb;48:83-92. doi: 10.1016/j.sbi.2017.10.020. Epub 2017 Nov 12. Curr Opin Struct Biol. 2018. PMID: 29141202 Free article. Review.
Evolution of chalcone isomerase from a noncatalytic ancestor.
Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel JP, Tawfik DS. Kaltenbach M, et al. Among authors: kamerlin scl. Nat Chem Biol. 2018 Jun;14(6):548-555. doi: 10.1038/s41589-018-0042-3. Epub 2018 Apr 23. Nat Chem Biol. 2018. PMID: 29686356
The evolution of multiple active site configurations in a designed enzyme.
Hong NS, Petrović D, Lee R, Gryn'ova G, Purg M, Saunders J, Bauer P, Carr PD, Lin CY, Mabbitt PD, Zhang W, Altamore T, Easton C, Coote ML, Kamerlin SCL, Jackson CJ. Hong NS, et al. Among authors: kamerlin scl. Nat Commun. 2018 Sep 25;9(1):3900. doi: 10.1038/s41467-018-06305-y. Nat Commun. 2018. PMID: 30254369 Free PMC article.
Harnessing Conformational Plasticity to Generate Designer Enzymes.
Crean RM, Gardner JM, Kamerlin SCL. Crean RM, et al. Among authors: kamerlin scl. J Am Chem Soc. 2020 Jul 1;142(26):11324-11342. doi: 10.1021/jacs.0c04924. Epub 2020 Jun 17. J Am Chem Soc. 2020. PMID: 32496764 Free PMC article. Review.
149 results