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Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.
EMBO J. 2017 Oct 16;36(20):2951-2967. doi: 10.15252/embj.201696394. Epub 2017 Aug 8.
EMBO J. 2017.
PMID: 28790177
Free PMC article.
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.
Burke KA, Janke AM, Rhine CL, Fawzi NL.
Burke KA, et al. Among authors: janke am.
Mol Cell. 2015 Oct 15;60(2):231-41. doi: 10.1016/j.molcel.2015.09.006. Epub 2015 Oct 8.
Mol Cell. 2015.
PMID: 26455390
Free PMC article.
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Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment.
Janke AM, Seo DH, Rahmanian V, Conicella AE, Mathews KL, Burke KA, Mittal J, Fawzi NL.
Janke AM, et al.
Biochemistry. 2018 May 1;57(17):2549-2563. doi: 10.1021/acs.biochem.7b00310. Epub 2017 Oct 11.
Biochemistry. 2018.
PMID: 28945358
Free PMC article.
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Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads.
Murthy AC, Tang WS, Jovic N, Janke AM, Seo DH, Perdikari TM, Mittal J, Fawzi NL.
Murthy AC, et al. Among authors: janke am.
Nat Struct Mol Biol. 2021 Nov;28(11):923-935. doi: 10.1038/s41594-021-00677-4. Epub 2021 Nov 10.
Nat Struct Mol Biol. 2021.
PMID: 34759379
Free PMC article.
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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L.
Boeynaems S, et al. Among authors: janke am.
Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013.
Mol Cell. 2017.
PMID: 28306503
Free PMC article.
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