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Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients.
Russell JA, Vincent JL, Kjølbye AL, Olsson H, Blemings A, Spapen H, Carl P, Laterre PF, Grundemar L. Russell JA, et al. Among authors: kjolbye al. Crit Care. 2017 Aug 15;21(1):213. doi: 10.1186/s13054-017-1798-7. Crit Care. 2017. PMID: 28807037 Free PMC article. Clinical Trial.
Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.
Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC. Mebazaa A, et al. Among authors: kjolbye al. J Intensive Care. 2016 Mar 31;4:24. doi: 10.1186/s40560-016-0151-6. eCollection 2016. J Intensive Care. 2016. PMID: 27034779 Free PMC article. Review.
Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial.
Lewis RJ, Angus DC, Laterre PF, Kjølbye AL, van der Meulen E, Blemings A, Graves T, Russell JA, Carlsen JE, Jacobsen K, Yealy DM, Opal SM, Windeløv NA, François B, Perner A, Pickkers P, Berry SM. Lewis RJ, et al. Among authors: kjolbye al. Ann Am Thorac Soc. 2018 Feb;15(2):250-257. doi: 10.1513/AnnalsATS.201708-669SD. Ann Am Thorac Soc. 2018. PMID: 29388815 Clinical Trial.
Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.
Laterre PF, Berry SM, Blemings A, Carlsen JE, François B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windeløv NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brulé N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjølbye AL, Angus DC; SEPSIS-ACT Investigators. Laterre PF, et al. Among authors: kjolbye al. JAMA. 2019 Oct 15;322(15):1476-1485. doi: 10.1001/jama.2019.14607. JAMA. 2019. PMID: 31577035 Free PMC article.
Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury.
Pickkers P, Angus DC, Arend J, Bellomo R, van den Berg E, Bernholz J, Bestle M, Broglio K, Carlsen J, Doig CJ, Ferrer R, Joannidis M, Francois B, Doi K, Kellum JA, Laterre PF, Liu K, Mehta RL, Murray PT, Ostermann M, Pettilä V, Richards S, Young P, Zarbock A, Kjølbye AL. Pickkers P, et al. Among authors: kjolbye al. BMJ Open. 2023 Apr 3;13(4):e065613. doi: 10.1136/bmjopen-2022-065613. BMJ Open. 2023. PMID: 37012016 Free PMC article.
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation.
Axelsen LN, Lademann JB, Petersen JS, Holstein-Rathlou NH, Ploug T, Prats C, Pedersen HD, Kjølbye AL. Axelsen LN, et al. Among authors: kjolbye al. Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1560-70. doi: 10.1152/ajpregu.00392.2009. Epub 2010 Mar 31. Am J Physiol Regul Integr Comp Physiol. 2010. PMID: 20357025 Free article.
Metabolic and cardiac changes in high cholesterol-fructose-fed rats.
Axelsen LN, Pedersen HD, Petersen JS, Holstein-Rathlou NH, Kjølbye AL. Axelsen LN, et al. Among authors: kjolbye al. J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):292-6. doi: 10.1016/j.vascn.2010.02.009. Epub 2010 Feb 19. J Pharmacol Toxicol Methods. 2010. PMID: 20172035
21 results