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Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM, Serreze DV. Ratiu JJ, et al. J Immunol. 2017 Jun 1;198(11):4255-4267. doi: 10.4049/jimmunol.1700024. Epub 2017 May 1. J Immunol. 2017. PMID: 28461573 Free PMC article.
B-lymphocytes expressing an Ig specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice.
Leeth CM, Racine J, Chapman HD, Arpa B, Carrillo J, Carrascal J, Wang Q, Ratiu J, Egia-Mendikute L, Rosell-Mases E, Stratmann T, Verdaguer J, Serreze DV. Leeth CM, et al. Diabetes. 2016 Jul;65(7):1977-1987. doi: 10.2337/db15-1606. Epub 2016 Mar 9. Diabetes. 2016. PMID: 26961115 Free PMC article.
Anti-tumor effects of an ID antagonist with no observed acquired resistance.
Wojnarowicz PM, Escolano MG, Huang YH, Desai B, Chin Y, Shah R, Xu S, Yadav S, Yaklichkin S, Ouerfelli O, Soni RK, Philip J, Montrose DC, Healey JH, Rajasekhar VK, Garland WA, Ratiu J, Zhuang Y, Norton L, Rosen N, Hendrickson RC, Zhou XK, Iavarone A, Massague J, Dannenberg AJ, Lasorella A, Benezra R. Wojnarowicz PM, et al. NPJ Breast Cancer. 2021 May 24;7(1):58. doi: 10.1038/s41523-021-00266-0. NPJ Breast Cancer. 2021. PMID: 34031428 Free PMC article.
A mosaic analysis system with Cre or Tomato expression in the mouse.
Wang Q, Lin YY, Zhang B, Wu J, Roy S, Ratiu JJ, Xu Y, Dai M, Hale LP, Xiong Y, Li QJ, Zhuang Y. Wang Q, et al. Among authors: ratiu jj. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28212-28220. doi: 10.1073/pnas.2014308117. Epub 2020 Oct 26. Proc Natl Acad Sci U S A. 2020. PMID: 33106431 Free PMC article.