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miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.
Diabetes. 2018 Feb;67(2):256-264. doi: 10.2337/db17-0506. Epub 2017 Nov 3.
Diabetes. 2018.
PMID: 29101219
Free PMC article.
Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP.
Thielen L, Shalev A.
Thielen L, et al.
Curr Opin Endocrinol Diabetes Obes. 2018 Apr;25(2):75-80. doi: 10.1097/MED.0000000000000391.
Curr Opin Endocrinol Diabetes Obes. 2018.
PMID: 29356688
Free PMC article.
Review.
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Verapamil and beta cell function in adults with recent-onset type 1 diabetes.
Ovalle F, Grimes T, Xu G, Patel AJ, Grayson TB, Thielen LA, Li P, Shalev A.
Ovalle F, et al. Among authors: thielen la.
Nat Med. 2018 Aug;24(8):1108-1112. doi: 10.1038/s41591-018-0089-4. Epub 2018 Jul 9.
Nat Med. 2018.
PMID: 29988125
Free PMC article.
Clinical Trial.
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Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.
Xu G, Thielen LA, Chen J, Grayson TB, Grimes T, Bridges SL Jr, Tse HM, Smith B, Patel R, Li P, Evans-Molina C, Ovalle F, Shalev A.
Xu G, et al. Among authors: thielen la.
Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E723-E730. doi: 10.1152/ajpendo.00122.2019. Epub 2019 Aug 13.
Am J Physiol Endocrinol Metab. 2019.
PMID: 31408375
Free PMC article.
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Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.
Thielen LA, Chen J, Jing G, Moukha-Chafiq O, Xu G, Jo S, Grayson TB, Lu B, Li P, Augelli-Szafran CE, Suto MJ, Kanke M, Sethupathy P, Kim JK, Shalev A.
Thielen LA, et al.
Cell Metab. 2020 Sep 1;32(3):353-365.e8. doi: 10.1016/j.cmet.2020.07.002. Epub 2020 Jul 28.
Cell Metab. 2020.
PMID: 32726606
Free PMC article.
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Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes.
Xu G, Grimes TD, Grayson TB, Chen J, Thielen LA, Tse HM, Li P, Kanke M, Lin TT, Schepmoes AA, Swensen AC, Petyuk VA, Ovalle F, Sethupathy P, Qian WJ, Shalev A.
Xu G, et al. Among authors: thielen la.
Nat Commun. 2022 Mar 3;13(1):1159. doi: 10.1038/s41467-022-28826-3.
Nat Commun. 2022.
PMID: 35241690
Free PMC article.
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