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Page 1
Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments.
Crowell TA, Colby DJ, Pinyakorn S, Fletcher JLK, Kroon E, Schuetz A, Krebs SJ, Slike BM, Leyre L, Chomont N, Jagodzinski LL, Sereti I, Utay NS, Dewar R, Rerknimitr R, Chomchey N, Trichavaroj R, Valcour VG, Spudich S, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV254/SEARCH010 Study Group. Crowell TA, et al. Among authors: leyre l. Clin Infect Dis. 2018 May 2;66(10):1540-1549. doi: 10.1093/cid/cix1063. Clin Infect Dis. 2018. PMID: 29228130 Free PMC article.
Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size.
Teigler JE, Leyre L, Chomont N, Slike B, Jian N, Eller MA, Phanuphak N, Kroon E, Pinyakorn S, Eller LA, Robb ML, Ananworanich J, Michael NL, Streeck H, Krebs SJ; RV254/RV217 study groups. Teigler JE, et al. Among authors: leyre l. JCI Insight. 2018 May 17;3(10):e98420. doi: 10.1172/jci.insight.98420. eCollection 2018 May 17. JCI Insight. 2018. PMID: 29769442 Free PMC article.
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.
Colby DJ, Trautmann L, Pinyakorn S, Leyre L, Pagliuzza A, Kroon E, Rolland M, Takata H, Buranapraditkun S, Intasan J, Chomchey N, Muir R, Haddad EK, Tovanabutra S, Ubolyam S, Bolton DL, Fullmer BA, Gorelick RJ, Fox L, Crowell TA, Trichavaroj R, O'Connell R, Chomont N, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV411 study group. Colby DJ, et al. Among authors: leyre l. Nat Med. 2018 Jul;24(7):923-926. doi: 10.1038/s41591-018-0026-6. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892063 Free PMC article.
Upregulation of IL-32 Isoforms in Virologically Suppressed HIV-Infected Individuals: Potential Role in Persistent Inflammation and Transcription From Stable HIV-1 Reservoirs.
Zaidan SM, Leyre L, Bunet R, Larouche-Anctil E, Turcotte I, Sylla M, Chamberland A, Chartrand-Lefebvre C, Ancuta P, Routy JP, Baril JG, Trottier B, MacPherson P, Trottier S, Harris M, Walmsley S, Conway B, Wong A, Thomas R, Kaplan RC, Landay AL, Durand M, Chomont N, Tremblay CL, El-Far M; Canadian HIV and Aging Cohort Study. Zaidan SM, et al. Among authors: leyre l. J Acquir Immune Defic Syndr. 2019 Dec 15;82(5):503-513. doi: 10.1097/QAI.0000000000002185. J Acquir Immune Defic Syndr. 2019. PMID: 31714430 Free PMC article.
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection.
Leyre L, Kroon E, Vandergeeten C, Sacdalan C, Colby DJ, Buranapraditkun S, Schuetz A, Chomchey N, de Souza M, Bakeman W, Fromentin R, Pinyakorn S, Akapirat S, Trichavaroj R, Chottanapund S, Manasnayakorn S, Rerknimitr R, Wattanaboonyoungcharoen P, Kim JH, Tovanabutra S, Schacker TW, O'Connell R, Valcour VG, Phanuphak P, Robb ML, Michael N, Trautmann L, Phanuphak N, Ananworanich J, Chomont N; RV254/SEARCH010, RV304/SEARCH013, SEARCH011 study groups. Leyre L, et al. Sci Transl Med. 2020 Mar 4;12(533):eaav3491. doi: 10.1126/scitranslmed.aav3491. Sci Transl Med. 2020. PMID: 32132218 Free PMC article.
Continuous Prophylactic Antiretrovirals/Antiretroviral Therapy Since Birth Reduces Seeding and Persistence of the Viral Reservoir in Children Vertically Infected With Human Immunodeficiency Virus.
Massanella M, Puthanakit T, Leyre L, Jupimai T, Sawangsinth P, de Souza M, Suntarattiwong P, Kosalarksa P, Borkird T, Kanjanavanit S, Chokephaibulkit K, Hansudewechakul R, Petdachai W, Mitchell JL, Robb ML, Trautmann L, Ananworanich J, Chomont N; RV474/HIVNAT194 and RV475/HIVNAT 209 Study Groups. Massanella M, et al. Among authors: leyre l. Clin Infect Dis. 2021 Aug 2;73(3):427-438. doi: 10.1093/cid/ciaa718. Clin Infect Dis. 2021. PMID: 32504081 Free PMC article.
An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status.
Takata H, Mitchell JL, Pacheco J, Pagliuzza A, Pinyakorn S, Buranapraditkun S, Sacdalan C, Leyre L, Nathanson S, Kakazu JC, Intasan J, Prueksakaew P, Chomchey N, Phanuphak N, de Souza M, Haddad EK, Rolland M, Tovanabutra S, Vasan S, Hsu DC, Chomont N, Trautmann L; RV254/SEARCH010; RV304/SEARCH013. Takata H, et al. Among authors: leyre l. Cell Host Microbe. 2023 Sep 13;31(9):1494-1506.e4. doi: 10.1016/j.chom.2023.08.012. Cell Host Microbe. 2023. PMID: 37708852 Free PMC article.
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.
Uzzan M, Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S. Uzzan M, et al. Among authors: leyre l. Sci Transl Med. 2018 Oct 3;10(461):eaau4711. doi: 10.1126/scitranslmed.aau4711. Sci Transl Med. 2018. PMID: 30282696 Free PMC article. Clinical Trial.
The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection.
Goes LR, Sajani A, Sivro A, Olowojesiku R, Ray JC, Perrone I, Yolitz J, Girard A, Leyre L, Wibmer CK, Morris L, Gorini G, Franchini G, Mason RD, Roederer M, Mehandru S, Soares MA, Cicala C, Fauci AS, Arthos J. Goes LR, et al. Among authors: leyre l. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32566-32573. doi: 10.1073/pnas.2011501117. Epub 2020 Dec 7. Proc Natl Acad Sci U S A. 2020. PMID: 33288704 Free PMC article.
16 results